Invitrogen™ Phospho-ERK5 (Thr218, Tyr220) Polyclonal Antibody

Catalog No.	Quantity
44-612-G	100 μL

Catalog No. 44-612-G Supplier Invitrogen™ Supplier No. 44612G

Description

Rabbit Polyclonal Antibody

Phospho-ERK5 (Thr218, Tyr220) Polyclonal Antibody for Western Blot, ICC/IF

MAPK7 (ERK5) serine/threonine kinase is a member of the MAP kinase family and is involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. MAPK7 is activated by mitogen-activated protein kinase 5 (MAP2K5/MEK5) and is involved in downstream signaling processes of various receptors. In response to extracelluar signals, MAPK7 translocates to the cell nucleus where it regulates gene expression by phosphorylating and activating different transcription factors. Gene deletion of MAPK7 in mice results in defective blood vessel and cardiac development leading to embryonic lethality. MAPK7 has been shown to be critical for endothelial function and maintenance of blood vessel integrity. Four alternatively spliced transcript variants of this gene encoding two distinct isoforms have been reported. ERK5 is expressed in many adult tissues, abundantly in heart, placenta, lung, kidney and skeletal muscle, but is not detectable in liver.

Specifications

• Antigen: Phospho-ERK5 (Thr218, Tyr220)
• Applications: Western Blot, Immunocytochemistry
• Classification: Polyclonal
• Conjugate: Unconjugated
• Formulation: Dulbecco's PBS with 1mg/mL BSA and 0.05% sodium azide; pH 7.3
• Gene: MAPK7
• Gene Accession No.: Q13164
• Gene Alias: Big MAP kinase 1; BMK1; BMK-1; BMK1 kinase; BNhp-1; BNhp1 kinase; ERK4; ERK5; ERK-5; Erk5-T; extracellular signal regulated kinase 5; extracellular signal-regulated kinase 5; extracellular-signal-regulated kinase 5; MAP kinase 7; MAPK 7; Mapk7; mitogen activated protein kinase 7; mitogen-activated protein kinase 7; PRKM7
• Gene Symbols: MAPK7
• Host Species: Rabbit
• Immunogen: The antiserum was produced against a chemically synthesized phosphopeptide derived from the region of human ERK5 that contains threonine 218 and tyrosine 220. The sequence is conserved in mouse.
• Purification Method: Antigen affinity chromatography
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 5598
• Target Species: Human
• Content And Storage: -20°C
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG