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Invitrogen™ Phospho-FADD (Ser194) Polyclonal Antibody
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Catalog No. PIPA517807
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100 μL
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PIPA517807 100 μL
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Catalog No. PIPA517807 Supplier Invitrogen™ Supplier No. PA517807
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Description

Rabbit Polyclonal Antibody

It is not recommended to aliquot this antibody.

The protein encoded by this gene is an adaptor molecule that interacts with various cell surface receptors and mediates cell apoptotic signals. Through its C-terminal death domain, this protein can be recruited by TNFRSF6/Fas-receptor, tumor necrosis factor receptor, TNFRSF25, and TNFSF10/TRAIL-receptor, and thus it participates in the death signaling initiated by these receptors. Interaction of this protein with the receptors unmasks the N-terminal effector domain of this protein, which allows it to recruit caspase-8, and thereby activate the cysteine protease cascade. Knockout studies in mice also suggest the importance of this protein in early T cell development.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Phospho-FADD (Ser194)
Applications Western Blot
Classification Polyclonal
Conjugate Unconjugated
Formulation 0.01M HEPES with 100μg/mL BSA, 50% glycerol, 0.15M NaCl and no preservative; pH 7.5
Gene FADD
Gene Accession No. Q13158
Gene Alias Fadd; Fas (TNFRSF6)-associated via death domain; Fas associated via death domain; FAS-associated death domain protein; FAS-associating death domain-containing protein; Fas-associating protein with death domain; GIG3; Growth-inhibiting gene 3 protein; mediator of receptor induced toxicity; mediator of receptor-induced toxicity; MGC8528; MORT1; Mort1/FADD; protein FADD
Gene Symbols FADD
Host Species Rabbit
Immunogen Synthetic phosphopeptide corresponding to residues surrounding pSer194 of human FADD.
Purification Method Antigen Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 8772
Target Species Human
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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