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Invitrogen™ Phospho-FOXO1/FOXO3/FOXO4 (Thr24, Thr32) Polyclonal Antibody
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Catalog No. PIPA5104979
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PIPA5104979 100 μL
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Catalog No. PIPA5104979 Supplier Invitrogen™ Supplier No. PA5104979
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Description

Rabbit Polyclonal Antibody

Antibody detects endogenous levels of pan-FOXO1/3/4 only when phosphorylated at Threonine 24/32.

FOXO1 + FOX3 + FOX4 belong to the forkhead family of transcription factors. FOXO1 (FKHR or ForkHead in Rhabdomyosarcoma) is a 70 kDa protein. Recent studies have shown that this protein can act as either a coactivator or a corepressor of nuclear receptor activity. This action is mediated through the LXXLL motif found in the C terminus of the FOXO1A protein. The specific function of the gene has not yet been determined.FOX3 probably functions as a trigger for apoptosis through expression of genes necessary for cell death. Translocation of the FOXO3 gene with the MLL gene is associated with secondary acute leukemia.FOX4 is a forkhead transcription factor involved in the regulation of the insulin signaling pathway. It binds to insulin-response elements (IREs) and can activate transcription of IGFBP1. FOXO4 down-regulates expression of HIF1A and suppresses hypoxia-induced transcriptional activation of HIF1A-modulated genes. It is also involved in negative regulation of the cell cycle.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Phospho-FOXO1/FOXO3/FOXO4 (Thr24, Thr32)
Applications Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene FOXO3
Gene Accession No. G3V7R4, O43524, P98177, Q12778, Q9R1E0, Q9WVH3, Q9WVH4
Gene Alias 1110048B16Rik; 2010203A17Rik; AF6q21; AF6q21 protein; AFX; AFX1; Afxh; AI876417; C76856; FKH1; FKHR; Fkhr1; Fkhr2; Fkhr3; FKHRL1; FKHRL1P2; fork head domain transcription factor AFX1; forkhead box O1; forkhead box O1a; forkhead box O1A (rhabdomyosarcoma); forkhead box O3; forkhead box O3A; forkhead box O4; forkhead box protein O1; Forkhead box protein O1A; forkhead box protein O3; Forkhead box protein O4; forkhead homolog (rhabdomyosarcoma) like 1; forkhead in rhabdomyosarcoma; Forkhead in rhabdomyosarcoma-like 1; forkhead protein; forkhead protein 1; forkhead protein FKHR2; forkhead, Drosophila, homolog of, in rhabdomyosarcoma; forkhead, Drosophila, homolog of, in rhabdomyosarcoma-like 1; Foxo1; FOXO1A; FOXO2; FOXO3; Foxo3a; FOXO4; MGC120490; Mllt7; myeloid/lymphoid or mixed lineage-leukemia translocation to 7 homolog; myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 7; RGD1561201
Gene Symbols FOXO1, FOXO3, FOXO4
Host Species Rabbit
Immunogen A synthesized peptide derived from human FOXO1(Accession Q12778), corresponding to amino acid residues around phosphorylated Thr24.
Purification Method Sequential chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 2308, 2309, 294515, 302415, 4303, 54601, 56458, 56484, 84482
Target Species Human, Mouse, Rat
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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