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Invitrogen™ Phospho-GAB1 (Tyr659) Polyclonal Antibody
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Catalog No. PIPA536908
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100 μL
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PIPA536908 100 μL
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Catalog No. PIPA536908 Supplier Invitrogen™ Supplier No. PA536908
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Description

Rabbit Polyclonal Antibody

This antibody detects endogenous protein at a molecular weight of 76 and 110 kDa. Purity is >95% by SDS-PAGE.

Gab1 is a 115 kDa multiple docking protein that plays an essential role in cellular growth, transformation and apoptosis. Gab1 can be phosphorylated by multiple receptor tyrosine kinase (RTKs), including: insulin receptor (IR), platelet-derived growth factor receptor beta] (PDGFRbeta]), hepatocyte growth factor/scatter factor receptor (HGFR/SFR or c-Met), and epidermal growth factor receptor (EGF), as well as in response to cell-cell adhesion. Gab1 is tyrosine phosphorylated on at least 16 sites, some of which serve as binding sites for phosphoatidylinositol 3-kinase (PI3K), Grb2, PLC gamma 1, Nck, and SHP2. Phosphorylation of Gab1 on tyrosines 627 and 659 is critical for its binding to SHP2, and for activation of the ERK/MAPK pathway in response to EGF.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Phospho-GAB1 (Tyr659)
Applications Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.2
Gene GAB1
Gene Accession No. Q13480, Q9QYY0
Gene Alias AA408973; AW107238; EGK_16125; GAB1; GRB2 associated binding protein 1; GRB2-associated binder 1; GRB2-associated binding protein 1; GRB2-associated binding protein 1 long isoform; GRB2-associated-binding protein 1; Growth factor receptor bound protein 2-associated protein 1; OTTHUMP00000220263
Gene Symbols GAB1
Host Species Rabbit
Immunogen Synthetic phosphopeptide derived from human Gab 1 around the phosphorylation site of Tyrosine 659.
Purification Method Antigen Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 14388, 2549, 361388
Target Species Human, Mouse, Rat
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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