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  6. Invitrogen™ Phospho-gamma-H2AX (Ser139) Recombinant Rabbit Monoclonal Antibody (BLR053F)

Invitrogen™ Phospho-gamma-H2AX (Ser139) Recombinant Rabbit Monoclonal Antibody (BLR053F)

Catalog No. PIMA544300
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Quantity:
10 μL
100 μL
Catalog No. Quantity
PIMA544300 10 μL
PIMA544299 100 μL
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Catalog No. PIMA544300

Supplier: Invitrogen™ MA544300

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Description

Rabbit Recombinant Monoclonal Antibody

Epitope retrieval with citrate buffer pH6.0 is recommended for FFPE cell sections.

H2AX is a variant of the H2A protein family and is a component of the histone octomer in nucleosomes. H2AX is phosphorylated by kinases such as ataxia telangiectasia mutated (ATM) and ATM-Rad3-related (ATR) in the PI3K pathway. Gamma-H2AX is the first step in recruiting and localizing DNA repair proteins. DSBs can be induced by mechanisms such as ionizing radiation or cytotoxic agents and subsequently, gamma-H2AX foci quickly form. These foci represent the DSBs in a 1:1 manner and can be used as a biomarker for damage. The visualization of gamma-H2AX by can allow the assessment of DNA damage, related DNA damage proteins and DNA repair. Gamma-H2AX has applications in the detection of genomic damage caused by cytotoxic chemical agents and environmental and physical damage.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Phospho-gamma-H2AX (Ser139)
Applications Flow Cytometry, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot, Immunocytochemistry
Classification Recombinant Monoclonal
Clone BLR053F
Concentration 100 μg/mL
Conjugate Unconjugated
Formulation BBS with 0.1% BSA and 0.09% sodium azide; pH 8.2
Gene H2AX
Gene Accession No. P16104
Gene Alias gamma H2A X; gamma H2A.X; gamma-H2A.X; gh2ax
Gene Symbols H2AX
Host Species Rabbit
Immunogen Peptide surrounding phosphorylated serine 140 of human histone H2AX.
Purification Method purified
Quantity 10 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 3014
Target Species Human
Content And Storage 4°C
Product Type Antibody
Form Liquid
Isotype IgG
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