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Invitrogen™ Phospho-GRB10 (Ser476) Polyclonal Antibody
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Catalog No. PIPA5104597
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PIPA5104597 100 μL
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Catalog No. PIPA5104597 Supplier Invitrogen™ Supplier No. PA5104597
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Description

Rabbit Polyclonal Antibody

Antibody detects endogenous levels of GRB10 only when phosphorylated at Ser476.

GRB7, a SH2 domain protein, has a single SH2 domain at its C-terminal, a central region with similarity to Ras GAP, and a proline-rich N terminus. A related SH2 domain-containing protein, GRB10, exhibits a high degree of homology with GRB7. GRB10 undergoes serine but not tyrosine phosphorylation in response to EGF treatment, but appears to bind to the EGF receptor poorly. GRB10 maps to mouse chromosome 11, in close proximity to the EGF receptor. Similarly, GRB7 maps to the same mouse chromosome near the EGF receptor-related protein HER2.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Phospho-GRB10 (Ser476)
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene GRB10
Gene Accession No. P0CE43, Q13322, Q60760
Gene Alias 5730571D09Rik; AI325020; Grb10; Grb-10; GRB10 adapter protein; GRB10 adaptor protein; GRBIR; GRB-IR; growth factor receptor bound protein 10; growth factor receptor-bound protein 10; Insulin receptor-binding protein Grb-IR; IRBP; KIAA0207; maternally expressed gene 1; maternally expressed gene 1 protein; Meg1; mKIAA0207; OTTHUMP00000197988; OTTHUMP00000197989; OTTHUMP00000197990; OTTHUMP00000197991; OTTHUMP00000197993; OTTHUMP00000197994; RGD1566234; RSS
Gene Symbols GRB10
Host Species Rabbit
Immunogen A synthesized peptide derived from human GRB10(Accession Q13322), corresponding to amino acid residues around phosphorylated Ser476.
Purification Method sequential chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 14783, 2887, 498416
Target Species Human, Mouse, Rat
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

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