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Invitrogen™ Phospho-GRK1/GRK2 (Tyr13) Polyclonal Antibody
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Catalog No. PIPA5118740
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PIPA5118740 100 μL
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Catalog No. PIPA5118740 Supplier Invitrogen™ Supplier No. PA5118740
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Description

Rabbit Polyclonal Antibody

Antibody detects endogenous levels of GRK1/2 only when phosphorylated at Tyr13.

The sensation of sight is the result of a cascade of events starting with the interaction of photoactivated rhodopsin with a protein called transducin. Rhodopsin kinase is a G-protein-coupled Ser/Thr kinase, also known as GRK1, which is a key element in the regulation of this cascade. Following phosphorylation by GRK1, arrestin is recruited to phospho-rhodopsin quenching its phototransductive activity by preventing further interaction with transducin. By breaking the cycle of phototransduction, GRK1 plays an important role in the restoration of the system for subsequent visual events.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Phospho-GRK1/GRK2 (Tyr13)
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene GRK2
Gene Accession No. P25098, P26817, Q15835, Q63651, Q99MK8, Q9WVL4
Gene Alias ADRBK1; Adrbk-1; adrenergic beta receptor kinase 1; adrenergic receptor kinase, beta 1; adrenergic, beta, receptor kinase 1; BARK; BARK1; Bark-1; beta ARK; beta-adrenergic receptor kinase 1; beta-adrenergic receptor kinase 1 beta ARK1; beta-AR kinase-1; betaARK1; BETA-ARK1; beta-ARK-1; G protein-coupled receptor kinase 1; G protein-coupled receptor kinase 2; G protein-coupled receptpr kinase 1; GPRK1; G-protein coupled receptor kinase 2; G-protein receptor kinase 1; G-protein-coupled receptor kinase 2; grk 2; GRK1; Grk2; GRK-2; rhodopsin kinase; Rhodopsin kinase GRK1; Rhok; Rk
Gene Symbols GRK1, GRK2
Host Species Rabbit
Immunogen A synthesized peptide derived from human GRK2(Accession P25098), corresponding to amino acid residues around phosphorylated Tyr13.
Purification Method Sequential chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 110355, 156, 24013, 25238, 6011, 81760
Target Species Human, Mouse, Rat
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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