Invitrogen™ Phospho-GSK3B (Tyr216, Tyr279) Polyclonal Antibody

Catalog No.	Quantity
44-604-G	100 μL

Catalog No. 44-604-G Supplier Invitrogen™ Supplier No. 44604G

Description

Rabbit Polyclonal Antibody

Phospho-GSK3B (Tyr216, Tyr279) Polyclonal Antibody for ELISA, Western Blot

GSK3B is a proline-directed serine/threonine protein kinase involved in energy metabolism, neuronal cell development and body pattern formation. It is a negative regulator of glucose homeostasis and is involved in energy metabolism, inflammation, ER-stress, mitochondrial dysfunction, and apoptotic pathways. GSK3B is a critical component of the Wnt/beta-catenin signaling pathway, and its activity results in the inhibition of Wnt signaling by mediating the degradation of beta-catenin. GSK3B is also involved in the Hedgehog, Notch, and insulin signaling pathways.

Specifications

• Antigen: Phospho-GSK3B (Tyr216, Tyr279)
• Applications: ELISA, Western Blot
• Classification: Polyclonal
• Conjugate: Unconjugated
• Formulation: Dulbecco's PBS with 1mg/mL BSA and 0.05% sodium azide; pH 7.3
• Gene: GSK3B
• Gene Accession No.: P18266, P49841, Q9WV60
• Gene Alias: 7330414F15Rik; 8430431H08Rik; C86142; EC 2.7.11.26; FA; Factor A; fb68h05; fk80d11; glycogen synthase kinase 3; glycogen synthase kinase 3 beta; glycogen synthase kinase 3 beta L homeolog; glycogen synthase kinase 3 beta variant 1; glycogen synthase kinase 3 beta variant 2; glycogen synthase kinase 3 beta variant 3; glycogen synthase kinase 3 beta variant 4; glycogen synthase kinase 3 beta variant 5; glycogen synthase kinase 3 beta, genome duplicate a; glycogen synthase kinase-3 beta; glycogen synthase kinase-3 beta splice variant X1; glycogen synthase kinase-3 beta splice variant X2; glycogen synthase kinase-3 beta splice variant X3; GSK 3 beta; GSK 3B; gsk3; GSK-3; GSK3 beta; GSK-3 beta; GSK-3 beta GSK3B; GSK-3[b]; Gsk3b; GSK-3b; gsk3b.L; gsk3ba; gsk3beta; GSK-3beta; gsk3-beta; GSK3beta isoform; intracellular kinase; pp37; serine/threonine-protein kinase GSK3B; wu:fb68h05; wu:fk80d11; XELAEV_180112401mg; xgsk-3; Xgsk-3 protein
• Gene Symbols: GSK3B
• Host Species: Rabbit
• Immunogen: The antiserum was produced against a chemically synthesized phosphopeptide derived from a region of human GSK-3a/b that contains tyrosine 279/216. The sequence is conserved in rat and zebrafish GSK-3a and mouse, rat, frog and zebrafish GSK-3b.
• Purification Method: Antigen affinity chromatography
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 2932, 56637, 84027
• Target Species: Human, Mouse, Rat
• Content And Storage: -20°C
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG