Invitrogen™ Phospho-HSP20 (Ser16) Polyclonal Antibody

Catalog No.	Quantity
PIPA5104689	100 μL

Catalog No. PIPA5104689 Supplier Invitrogen™ Supplier No. PA5104689

Description

Rabbit Polyclonal Antibody

Antibody detects endogenous levels of HSP20 only when phosphorylated at Serine 16.

Heat Shock Protein 20 (HSP20), encoded by the HSPB6 gene, is a member of the small heat shock protein (sHSP) family, prominently involved in cellular stress response and maintenance of cytoskeletal integrity. HSP20 is ubiquitously expressed across various tissues, including cardiac and smooth muscle, where its roles are vital in modulating stress resilience and muscle function. It exerts protective effects against apoptosis and oxidative stress by interacting with cell signaling pathways that enhance cellular survival and protein stabilization. In cardiac muscle, HSP20 is known for its cardioprotective actions during ischemic injury, helping preserve myocardial function by inhibiting hypertrophic signaling pathways and promoting muscle relaxation. Studies highlight its involvement in vasodilation processes, as HSP20 interacts with myosin to regulate smooth muscle contraction and dilatation. Beyond its role in muscle physiology, HSP20 has been investigated for its potential therapeutic applications in cardiovascular diseases and metabolic disorders, where its expression and function could be pivotal in disease modulation and treatment strategies.

Specifications

• Antigen: Phospho-HSP20 (Ser16)
• Applications: Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Classification: Polyclonal
• Concentration: 1 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
• Gene: HSPB6
• Gene Accession No.: O14558, P97541, Q5EBG6
• Gene Alias: AA387366; cardiac heat shock protein p20; cardiac p20; epididymis luminal protein 55; Gm479; Heat shock 20 kDa-like protein p20; heat shock 20-kDa protein; Heat shock protein; heat shock protein 20kDa; heat shock protein beta-6; heat shock protein family B (small) member 6; heat shock protein family B (small) member B6; heat shock protein, alpha-crystallin-related, B6; HEL55; HSP; HSP20; HSPB6; p20; PPP1R91; protein phosphatase 1, regulatory subunit 91
• Gene Symbols: HSPB6
• Host Species: Rabbit
• Immunogen: A synthesized peptide derived from human HSPB6(Accession O14558), corresponding to amino acid residues around phosphorylated Ser16.
• Purification Method: Sequential chromatography
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 126393, 192245, 243912
• Target Species: Human, Mouse, Rat
• Content And Storage: -20°C
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov