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Invitrogen™ Phospho-HTRA2 (Ser142) Polyclonal Antibody
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Catalog No. PIPA5118742
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PIPA5118742 100 μL
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Catalog No. PIPA5118742 Supplier Invitrogen™ Supplier No. PA5118742
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Description

Rabbit Polyclonal Antibody

Antibody detects endogenous levels of HtrA2 only when phosphorylated at Ser142.

The inhibitor of apoptosis (IAP) family of proteins regulates programmed cell death triggered by various stimuli. All IAPs have at least one baculovirus IAP repeat (BIR) motif that is essential for their anti-apoptotic activity (1-3). Recently, a serine protease has been isolated, which is released from the mitochondria upon induction of apoptosis by apoptotic stimuli. This protein called Omi/HtrA2 is a mitochondrial protein that binds to IAP (4). Like Smac/DIABLO, the mature Omi protein contains a conserved IAP-binding motif (AVPS) at its N terminus. The deregulated expression of Omi in the cytoplasm of mammalian cells induces apoptosis indicating that Omi could participate in the mitochondrial apoptotic pathway.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Phospho-HTRA2 (Ser142)
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene HTRA2
Gene Accession No. O43464, Q9JIY5
Gene Alias AI481710; High temperature requirement protein A2; HtrA serine peptidase 2; HtrA2; HtrA-like serine protease; mnd2; motor neuron degeneration 2; OMI; Omi stress-regulated endoprotease; PARK13; protease, serine, 25; Prss25; Serine protease 25; serine protease HTRA2, mitochondrial; serine protease OMI; serine proteinase OMI
Gene Symbols HTRA2
Host Species Rabbit
Immunogen A synthesized peptide derived from human HTRA2(Accession O43464), corresponding to amino acid residues around phosphorylated Ser142.
Purification Method sequential chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 27429, 297376, 64704
Target Species Human, Mouse, Rat
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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