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Phospho-Insulin Receptor Beta (Tyr1355) Rabbit anti-Human, Polyclonal, Bioss Non-distribution product as customer accommodation.

Rabbit Polyclonal Antibody

Manufacturer:  BiossSupplier Diversity Partner BS3492R

Catalog No. 50-198-5445


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Description

Description

Biological actions of insulin and IGF-1 are mediated by their respective cell surface receptor tyrosine kinases that regulate multiple signaling pathways through activation of a series of phosphorylation cascades. The insulin receptor. Insulin/IGF-1 binding to the extracellular domain leads to autophosphorylation of downstream target proteins. These two receptors differ in sequence in regions that confer specificity for the designated ligand as well as in certain intracellular signaling domains, resulting in significant differences in the functional consequences of activation of each receptor. Defects in IR are the cause of various insulin resistance syndromes and IGF-1R defects may cause some forms of growth retardation. Both these signaling cascades are also important for the development of cancer.
Specifications

Specifications

Phospho-Insulin Receptor Beta (Tyr1355)
Immunofluorescence, Immunohistochemistry (Paraffin)
Unconjugated
INSR
Liquid
Rabbit
IgG
100 μL
-20°C
Primary
3643
INSR
1 μg/mL
PBS with 1% BSA, 50% glycerol and 0.09% sodium azide; pH
P06213
4932439J01Rik; CD220; CD220 beta; CD221; D630014A15Rik; HHF5; IGF-I receptor; Insr; Insulin receptor; insulin receptor preproprotein; Insulin receptor subunit alpha; Insulin receptor subunit beta; IR; IR beta; IR-A; IR-B
KLH conjugated synthetic phosphopeptide derived from human Insulin Receptor beta around the phosphorylation site of Tyr1355 [RS (p-Y)EE].
Protein A
RUO
Antibody
Polyclonal
Human
SDS
Documents
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