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Invitrogen™ Phospho-IRAK1 (Thr209) Polyclonal Antibody
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Catalog No. PIPA5105183
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PIPA5105183 100 μL
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Catalog No. PIPA5105183 Supplier Invitrogen™ Supplier No. PA5105183
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Description

Rabbit Polyclonal Antibody

Application note: This antibody has also been used in peptide-ELISA Antibody detects endogenous levels of IRAK1 only when phosphorylated at Thr209.

IL-1 receptor associated kinases (IRAKs) are serine/threonine kinases involved in signaling via Toll/IL-1 pathways. It is rapidly recruited by MYD88 to the receptor-signaling complex upon TLR activation. IRAK's association with MYD88 leads to IRAK1 phosphorylation by IRAK4 and subsequent autophosphorylation and kinase activation. Alternatively, IRAK1 can phosphorylate TIRAP to promote its ubiquitination and subsequent degradation. IRAK1 also phosphorylates the interferon regulatory factor 7 (IRF7) to induce its activation and translocation to the nucleus. This results in the transcriptional activiation of type I IFN genes, which drive the cell in an antiviral state.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Phospho-IRAK1 (Thr209)
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene Irak1
Gene Accession No. P51617, Q62406
Gene Alias AA408924; Il1rak; interleukin 1 receptor associated kinase 1; interleukin-1 receptor-associated kinase 1; interleukin-1 receptor-associated kinase-1; IRAK; Irak1; IRAK-1; IRAK1-S; mPLK; pelle; Pelle homolog; pelle-like protein kinase; Plpk; RGD1563841
Gene Symbols Irak1
Host Species Rabbit
Immunogen A synthesized peptide derived from human IRAK1(Accession P51617), corresponding to amino acid residues around phosphorylated Thr209.
Purification Method Sequential Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 16179, 363520, 3654
Target Species Human, Mouse, Rat
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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