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Invitrogen™ Phospho-IRF3 (Ser386) Polyclonal Antibody
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Catalog No. PIPA5121307
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100 μL
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PIPA5121307 100 μL
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Catalog No. PIPA5121307 Supplier Invitrogen™ Supplier No. PA5121307
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Description

Rabbit Polyclonal Antibody

Positive test controls include: HeLa, NIH/3T3. The target is usually found in the following locations: Cytoplasm, Nucleus. Immunogen sequence: ASSLE.

IFR3 (interferon regulatory factor 3) is a key transcriptional regulator of type I interferon (IFN)-dependent immune responses. It plays a critical role in the innate immune response against DNA and RNA viruses. IFR3 regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN-stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters. It acts as a more potent activator of the IFN-beta gene than the IFN-alpha gene and plays a critical role in both the early and late phases of the IFNA/B gene induction. IFR3 is found in an inactive form in the cytoplasm of uninfected cells and following viral infection, double-stranded RNA, or toll-like receptor signaling. It is phosphorylated by IKBKE and TBK1 kinases. This induces a conformational change, leading to its dimerization and nuclear localization and association with CREB binding protein to form dsRNA-activated factor 1 (DRAF1), a complex which activates the transcription of the type I IFN and ISG genes. Mutations in the gene can result in encephalopathy, acute, infection-induced, herpes-specific 7.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Phospho-IRF3 (Ser386)
Applications ELISA, Western Blot
Classification Polyclonal
Concentration 5.4 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.09% sodium azide; pH 7.3
Gene IRF3
Gene Accession No. P70671, Q14653
Gene Alias C920001K05Rik; IIAE7; Interferon regulatory factor 3; IRF3; IRF-3; IRF3 (phospho S386); IRF3 (pS386); IRF3 (pSer386); IRF3 phospho; IRF3 phospho S386; IRF3 phospho Ser386; phospho IRF3
Gene Symbols IRF3
Host Species Rabbit
Immunogen A synthetic phosphorylated peptide around S386 of human IRF3 (NP_001562.1).
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 292892, 3661, 54131
Target Species Human, Mouse, Rat
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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