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Invitrogen™ Phospho-IRF7 (Ser477) Polyclonal Antibody
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Catalog No. PIPA5106184
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PIPA5106184 100 μL
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Catalog No. PIPA5106184 Supplier Invitrogen™ Supplier No. PA5106184
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Description

Rabbit Polyclonal Antibody

Antibody detects endogenous levels of IRF7 only when phosphorylated at Ser477.

Interferons (IFNs) are involved in a multitude of immune interactions during viral infections and play a major role in both the induction and regulation of innate and adaptive antiviral mechanisms. During infection, host-virus interactions signal downstream molecules such as transcription factors such as IFN regulatory factor-3 (IRF3) which can act to stimulate transcription of IFN-a/b genes. IRF7 has been shown to play a role in the transcriptional activation of virus-inducible cellular genes, including interferon beta chain genes. IRF7 play a major role in the innate immune pathway, interacting with the Toll-like receptor (TLR) adaptor proteins MyD88 and Tirp/TRAM and functioning as an intermediate TLR4 and TLR9 signaling. There are at least four differentially spliced isoforms of IRF7, although their function has not been clearly established.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Phospho-IRF7 (Ser477)
Applications Immunohistochemistry, Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene IRF7
Gene Accession No. P70434, Q92985
Gene Alias IMD39; Interferon regulatory factor 7; interferon regulatory factor-7H; Irf7; IRF-7; IRF7A; IRF7B; IRF7C; IRF7H; IRF-7H
Gene Symbols IRF7
Host Species Rabbit
Immunogen A synthesized peptide derived from human IRF7(Accession Q92985), corresponding to amino acid residues around phosphorylated Ser477.
Purification Method Sequential chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 293624, 3665, 54123
Target Species Human, Mouse, Rat
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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