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Invitrogen™ Phospho-JAK1 (Tyr1022) Polyclonal Antibody
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Catalog No. PIPA536657
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100 μL
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Catalog No. Quantity
PIPA536657 100 μL
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Catalog No. PIPA536657 Supplier Invitrogen™ Supplier No. PA536657
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Description

Rabbit Polyclonal Antibody

This antibody detects endogenous protein at a molecular weight of 132 kDa. Purity is >95% by SDS-PAGE.

Janus kinase 1 (JAK1), is a protein tyrosine kinase that is involved in the interferon-alpha/beta and -gamma signal transduction pathways. Immunological stimuli, such as interferons and cytokines, induce recruitment of Stat transcription factors to cytokine receptor-associated JAK1. JAK1 then phosphorylates proximal Stat factors, which subsequently dimerize, translocate to the nucleus and bind to cis elements upstream of target gene promoters to regulate transcription. Upon ligand binding, JAK1 undergoes tyrosine phosphorylation and catalytic activation in an interdependent manner. Phosphorylation of tyrosine residues at positions 1022 and 1023 is believed to function in the activation of catalytic events.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Phospho-JAK1 (Tyr1022)
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.2
Gene JAK1
Gene Accession No. P23458, P52332
Gene Alias AA960307; BAP004; C130039L05Rik; EC 2.7.10.2; Jak1; JAK-1; JAK1A; JAK1B; Janus kinase 1; Janus protein tyrosine kinase 1; JTK3; kinase Jak1; Tyrosine-protein kinase JAK1
Gene Symbols JAK1
Host Species Rabbit
Immunogen Synthetic phosphopeptide derived from human JAK1 around the phosphorylation site of Tyrosine 1022.
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 16451, 3716, 84598
Target Species Human, Mouse, Rat
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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