Invitrogen™ Phospho-Jak1 (Tyr1034, Tyr1035) Recombinant Rabbit Monoclonal Antibody (Jak1Y10221023-F11), FITC

Rabbit Recombinant Monoclonal Antibody

Supplier:  Invitrogen™ MA536892

Catalog No. PIMA536892

Description

Phospho-Jak1 (Tyr1034, Tyr1035) Recombinant Monoclonal Antibody for Flow

Janus kinase 1 (JAK1), is a protein tyrosine kinase that is involved in the interferon-alpha/beta and -gamma signal transduction pathways. Immunological stimuli, such as interferons and cytokines, induce recruitment of Stat transcription factors to cytokine receptor-associated JAK1. JAK1 then phosphorylates proximal Stat factors, which subsequently dimerize, translocate to the nucleus and bind to cis elements upstream of target gene promoters to regulate transcription. Upon ligand binding, JAK1 undergoes tyrosine phosphorylation and catalytic activation in an interdependent manner. Phosphorylation of tyrosine residues at positions 1022 and 1023 is believed to function in the activation of catalytic events.

Specifications

• Antigen: Phospho-Jak1 (Tyr1034, Tyr1035)
• Classification: Recombinant Monoclonal
• Conjugate: FITC
• Gene: JAK1
• Gene Alias: AA960307; BAP004; C130039L05Rik; EC 2.7.10.2; Jak1; JAK-1; JAK1A; JAK1B; Janus kinase 1; Janus protein tyrosine kinase 1; JTK3; kinase Jak1; Tyrosine-protein kinase JAK1
• Host Species: Rabbit
• Purification Method: Protein A/G
• Regulatory Status: RUO
• Gene ID (Entrez): 3716
• Content And Storage: 4°C, store in dark
• Form: Liquid

• Applications: Flow Cytometry
• Clone: Jak1Y10221023-F11
• Formulation: PBS with 0.20% BSA and 0.09% sodium azide
• Gene Accession No.: P23458
• Gene Symbols: JAK1
• Immunogen: A synthetic phospho-peptide corresponding to residues surrounding Tyr1034/1035 of human phospho-Jak1.
• Quantity: 10 Tests
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG κ

Safety and Handling

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