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Invitrogen™ Phospho-JAK1 (Tyr1034, Tyr1035) Polyclonal Antibody
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Catalog No. 44422G
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44-422-G 100 μL
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Catalog No. 44-422-G Supplier Invitrogen™ Supplier No. 44422G
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Description

Rabbit Polyclonal Antibody

This product was formerly called 'Phospho-JAK1 (Tyr1022, Tyr1023) Polyclonal Antibody' because Human Jak1 residues Tyr1034 and Tyr1035 have been historically referenced as Tyr1022 and Tyr1023.

Janus kinase 1 (JAK1), is a protein tyrosine kinase that is involved in the interferon-alpha/beta and -gamma signal transduction pathways. Immunological stimuli, such as interferons and cytokines, induce recruitment of Stat transcription factors to cytokine receptor-associated JAK1. JAK1 then phosphorylates proximal Stat factors, which subsequently dimerize, translocate to the nucleus and bind to cis elements upstream of target gene promoters to regulate transcription. Upon ligand binding, JAK1 undergoes tyrosine phosphorylation and catalytic activation in an interdependent manner. Phosphorylation of tyrosine residues at positions 1022 and 1023 is believed to function in the activation of catalytic events.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Phospho-JAK1 (Tyr1034, Tyr1035)
Applications Western Blot, Immunocytochemistry
Classification Polyclonal
Conjugate Unconjugated
Formulation Dulbecco's PBS with 1mg/mL BSA and 0.05% sodium azide; pH 7.3
Gene JAK1
Gene Accession No. P23458, P52332
Gene Alias AA960307; BAP004; C130039L05Rik; EC 2.7.10.2; Jak1; JAK-1; JAK1A; JAK1B; Janus kinase 1; Janus protein tyrosine kinase 1; JTK3; kinase Jak1; Tyrosine-protein kinase JAK1
Gene Symbols JAK1
Host Species Rabbit
Immunogen The antiserum was produced against a chemically synthesized phosphopeptide derived from a region of human JAK1 protein that contains tyrosines 1034 and 1035. The sequence is conserved in mouse and pig.
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 16451, 3716
Target Species Human, Mouse
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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