Phospho-Jak1 (Tyr1022, Tyr1023) Recombinant Rabbit Monoclonal Antibody (Jak1Y10221023-F11), Invitrogen™

Rabbit Recombinant Monoclonal Antibody

Catalog Number	Mfr. No.	Quantity
PIMA537415	Invitrogen™ MA537415	20 μL
PIMA537168	Invitrogen™ MA537168	200 μL

Description

Janus kinase 1 (JAK1), is a protein tyrosine kinase that is involved in the interferon-alpha/beta and -gamma signal transduction pathways. Immunological stimuli, such as interferons and cytokines, induce recruitment of Stat transcription factors to cytokine receptor-associated JAK1. JAK1 then phosphorylates proximal Stat factors, which subsequently dimerize, translocate to the nucleus and bind to cis elements upstream of target gene promoters to regulate transcription. Upon ligand binding, JAK1 undergoes tyrosine phosphorylation and catalytic activation in an interdependent manner. Phosphorylation of tyrosine residues at positions 1022 and 1023 is believed to function in the activation of catalytic events.

Specifications

• Antigen: Phospho-Jak1 (Tyr1034, Tyr1035)
• Concentration: 0.5 mg/mL
• Classification: Recombinant Monoclonal
• Form: Liquid
• Regulatory Status: RUO
• Formulation: PBS with 0.10% BSA, 50% glycerol and 0.02% sodium azide
• Gene Alias: AA960307; BAP004; C130039L05Rik; EC 2.7.10.2; Jak1; JAK-1; JAK1A; JAK1B; Janus kinase 1; Janus protein tyrosine kinase 1; JTK3; kinase Jak1; Tyrosine-protein kinase JAK1
• Gene Symbols: JAK1
• Isotype: IgG κ
• Purification Method: Protein A/G
• Product Type: Antibody

• Clone: Jak1Y10221023-F11
• Applications: Flow Cytometry
• Conjugate: Unconjugated
• Host Species: Rabbit
• Target Species: Human, Mouse
• Gene Accession No.: P23458, P52332
• Gene ID (Entrez): 16451, 3716
• Immunogen: A synthetic phospho-peptide corresponding to residues surrounding Tyr1034/1035 of human phospho-Jak1.
• Primary or Secondary: Primary
• Content And Storage: -20°C
• Gene: JAK1