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Invitrogen™ Phospho-JAK1 (Tyr1125) Polyclonal Antibody
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Catalog No. PIPA5105534
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100 μL
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PIPA5105534 100 μL
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Catalog No. PIPA5105534 Supplier Invitrogen™ Supplier No. PA5105534
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Description

Rabbit Polyclonal Antibody

Antibody detects endogenous levels of JAK1 only when phosphorylated at Tyr1125.

Janus kinase 1 (JAK1), is a protein tyrosine kinase that is involved in the interferon-alpha/beta and -gamma signal transduction pathways. Immunological stimuli, such as interferons and cytokines, induce recruitment of Stat transcription factors to cytokine receptor-associated JAK1. JAK1 then phosphorylates proximal Stat factors, which subsequently dimerize, translocate to the nucleus and bind to cis elements upstream of target gene promoters to regulate transcription. Upon ligand binding, JAK1 undergoes tyrosine phosphorylation and catalytic activation in an interdependent manner. Phosphorylation of tyrosine residues at positions 1022 and 1023 is believed to function in the activation of catalytic events.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Phospho-JAK1 (Tyr1125)
Applications Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene JAK1
Gene Accession No. P23458, P52332
Gene Alias AA960307; BAP004; C130039L05Rik; EC 2.7.10.2; Jak1; JAK-1; JAK1A; JAK1B; Janus kinase 1; Janus protein tyrosine kinase 1; JTK3; kinase Jak1; Tyrosine-protein kinase JAK1
Gene Symbols JAK1
Host Species Rabbit
Immunogen A synthesized peptide derived from human JAK1(Accession P23458), corresponding to amino acid residues around phosphorylated Tyr1125.
Purification Method Sequential chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 16451, 3716, 84598
Target Species Human, Mouse, Rat
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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