Invitrogen™ Phospho-KSR1 (Ser392) Recombinant Rabbit Monoclonal Antibody (KSR1S392-3A4)

Rabbit Recombinant Monoclonal Antibody

Catalog Number	Mfr. No.	Quantity
PIMA528079	Invitrogen™ MA528079	200 μL
PIMA537016	Invitrogen™ MA537016	20 μL

Description

Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.

Part of a multiprotein signaling complex which promotes phosphorylation of Raf family members and activation of downstream MAP kinases. Independently of its kinase activity, acts as MAP2K1/MEK1 and MAP2K2/MEK2-dependent allosteric activator of BRAF; upon binding to MAP2K1/MEK1 or MAP2K2/MEK2, dimerizes with BRAF and promotes BRAF-mediated phosphorylation of MAP2K1/MEK1 and/or MAP2K2/MEK2 (PubMed:29433126). Promotes activation of MAPK1 and/or MAPK3, both in response to EGF and to cAMP. Its kinase activity is unsure. Some protein kinase activity has been detected in vitro, however the physiological relevance of this activity is unknown. [UniProt].

Specifications

• Antigen: Phospho-KSR1 (Ser392)
• Concentration: 0.5 mg/mL
• Applications: Flow Cytometry
• Conjugate: Unconjugated
• Host Species: Rabbit
• Regulatory Status: RUO
• Formulation: PBS with 0.1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.4
• Gene Accession No.: Q61097, Q8IVT5
• Gene ID (Entrez): 16706, 8844
• Immunogen: A synthetic phospho-peptide corresponding to residues surrounding Ser392 of human phospho KSR1.
• Product Type: Antibody

• Clone: KSR1S392-3A4
• Content And Storage: -20°C
• Classification: Recombinant Monoclonal
• Form: Liquid
• Isotype: IgG κ
• Target Species: Human, Mouse
• Gene: KSR1
• Gene Alias: AW492498; B-KSR1; CAP kinase; D11Bhm183e; D11Bhm184e; hb; HB protein; kinase KSR1; Kinase suppressor of Ras 1; Ksr; KSR1; mKSR1; OTTHUMP00000162931; protein Hb; RSU2
• Gene Symbols: KSR1
• Primary or Secondary: Primary
• Purification Method: Protein A/G