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  6. Invitrogen™ Phospho-Lck (Tyr505) Recombinant Rabbit Monoclonal Antibody (LckY505-A3), FITC, Invitrogen™

Invitrogen™ Phospho-Lck (Tyr505) Recombinant Rabbit Monoclonal Antibody (LckY505-A3), FITC, Invitrogen™

Catalog No. PIMA537342
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Catalog No. PIMA537342 Supplier Invitrogen™ Supplier No. MA537342
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Description

Rabbit Recombinant Monoclonal Antibody

LCK is a member of the Src-family tyrosine kinase, which are essential for signaling through the T-cell receptor (TCR) complex. Upon TCR triggering, LCK phosphorylates the ITAM motives in its zeta subunits establishing binding sites for the SH2 domains of the tyrosine kinase ZAP70, which is also phosphorylated by LCK and activated to generate subsequent signaling platforms by phosphorylation of adaptor LAT. The majority of LCK is localized to the plasma membrane, however, there is also a significant fraction associated with the Golgi apparatus which may contribute to Raf activation under conditions of weak stimulation through the TCR. LCK contains N-terminal sites for myristylation and palmitylation, a PTK domain, and SH2 and SH3 domains which are involved in mediating protein-protein interactions with phosphotyrosine-containing and proline-rich motifs, respectively. LCK is also involved in the regulation of apoptosis induced by various stimuli, but not by the death receptors. Diseases associated with LCK include Immunodeficiency 22 and CD45 deficiency. Alternatively splice variants of the LCK gene encoding different isoforms of the protein have been found.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Phospho-Lck (Tyr505)
Applications Flow Cytometry
Classification Recombinant Monoclonal
Clone LckY505-A3
Conjugate FITC
Formulation PBS with 0.20% BSA and 0.09% sodium azide
Gene LCK
Gene Accession No. P06239
Gene Alias EC 2.7.10.2; Hck-3; IMD22; kinase Lck; Lck; LCK proto-oncogene, Src family tyrosine kinase; Lck1; Lcktkr; leukocyte C-terminal Src kinase; LSK; Lskt; Lsk-t; Lymphocyte cell-specific protein-tyrosine kinase; lymphocyte protein tyrosine kinase; lymphocyte-specific protein tyrosine kinase; OTTHUMP00000008640; OTTHUMP00000008740; OTTHUMP00000008741; p56(LSTRA) protein-tyrosine kinase; p56>lck>; p56lck; p56-LCK; pp58lck; Protein YT16; Proto-oncogene Lck; Proto-oncogene tyrosine-protein kinase LCK; RP4-675E8.4; t cell-specific protein-tyrosine kinase; T-lymphocyte specific protein tyrosine kinase p56lck; tyr; tyrosine-protein kinase Lck; YT16
Gene Symbols LCK
Host Species Rabbit
Immunogen A synthetic phospho-peptide corresponding to residues surrounding Tyr505 of human phospho Lck.
Purification Method Protein A/G
Quantity 10 Tests
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 3932
Target Species Human
Content And Storage 4°C, store in dark
Product Type Antibody
Form Liquid
Isotype IgG κ
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