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Invitrogen™ Phospho-LIMK1 (Tyr507, Thr508) Polyclonal Antibody
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Catalog No. 441076G
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44-107-6G 100 μL
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Catalog No. 44-107-6G Supplier Invitrogen™ Supplier No. 441076G
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Description

Rabbit Polyclonal Antibody

Phospho-LIMK1 (Tyr507, Thr508) Polyclonal Antibody for Western Blot

LIMK1 is a serine/threonine kinase involved in regulation of actin cytoskeletal changes via phosphorylation of cofilin. LIMK1 has also been implicated in brain development. LIM domains are highly conserved cysteine-rich structures containing 2 zinc fingers. Although zinc fingers usually function by binding to DNA or RNA, the LIM motif probably mediates protein-protein interactions. LIM kinase-1 and LIM kinase-2 belong to a small subfamily with a unique combination of 2 N-terminal LIM motifs and a C-terminal protein kinase domain. LIMK1 is likely to be a component of an intracellular signaling pathway and may be involved in brain development. LIMK1 hemizygosity is implicated in the impaired visuospatial constructive cognition of Williams syndrome.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Phospho-LIMK1 (Tyr507, Thr508)
Applications Western Blot
Classification Polyclonal
Conjugate Unconjugated
Formulation Dulbecco's PBS with 1mg/mL BSA and 0.05% sodium azide; pH 7.3
Gene LIMK1
Gene Accession No. P53667
Gene Alias EC 2.7.11.1; kinase LIMK1; KIZ-1; LIM domain kinase 1; lim kinase 1; LIM motif-containing protein kinase; LIM motif-containing protein kinase 1; LIM-domain containing protein kinase 1; LIM-domain containing, protein kinase; LIM-domain containing, protein kinase 1; Limk; LIMK1; LIMK-1
Gene Symbols LIMK1
Host Species Rabbit
Immunogen The antiserum was produced against a chemically synthesized phosphopeptide derived from the region of human LIMK1 that contains tyrosine 507 and threonine 508 (tyrosine 504 and threonine 505 in LIMK2). The LIMK1 sequence is conserved in mouse and rat, and the LIMK2 sequence is conserved in mouse, rat, and chicken.
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 3984
Target Species Human
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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