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Phospho-MAP3K8 (Thr290) Rabbit anti-Human, Polyclonal, Bioss
SDP

Catalog No. 501985417
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50-198-5417 100 μL
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Catalog No. 50-198-5417 Supplier Bioss Supplier No. BS3455R
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Description

Rabbit Polyclonal Antibody

Mitogen-activated protein kinase (MAPK) signaling cascades include MAPK or extracellular signal-regulated kinase (ERK), MAPK kinase (MKK or MEK), and MAPK kinase (MAPKKK or MEKK). MAPKK kinase/MEKK phosphorylates and activates its downstream protein kinase, MAPK kinase/MEK, which in turn activates MAPK. The kinases of these signaling cascades are highly conserved, and homologs exist in yeast, Drosophila, and mammalian cells. MEKK8 is able to activate NF-kappa-B 1 by stimulating proteasome-mediated proteolysis of NF-kappa-B 1/p105. The protein appears to play an important role in the cell cycle. This cytoplasmic protein is expressed in several normal tissues and human tumor-derived cell lines. The 58 kDa form is activated specifically during the S and G2/M phases of the cell cycle. The longer form undergoes phosphorylation on Ser residues mainly, and the shorter form on both Ser and Thr residues.

Specifications

Antigen Phospho-MAP3K8 (Thr290)
Applications Immunofluorescence, Immunohistochemistry (Paraffin)
Classification Polyclonal
Concentration 1 μg/mL
Conjugate Unconjugated
Formulation PBS with 1% BSA, 50% glycerol and 0.09% sodium azide; pH
Gene MAP3K8
Gene Accession No. P41279
Gene Alias augmented in rheumatoid arthritis 2; AURA2; Cancer Osaka thyroid oncogene; cancer Osaka thyroid, oncogene; CCOT; c-COT; COT; cot (cancer Osaka thyroid) oncogene; COT proto-oncogene serine/threonine-protein kinase; Cot/Tpl2; D17TPL2; EC 1.14.16.2; EST; ESTF; Ewing sarcoma transformant; FLJ10486; M3K8; MAP3K 8; MAP3K8; MEKK8; mitogen activated protein kinase kinase kinase 8; Mitogen-activated protein kinase kinase kinase 8; Protein kinase cot; Proto-oncogene c-Cot; proto-oncogene serine/threoine protein kinase; serine/threonine kinase (Tpl-2); Serine/threonine-protein kinase cot; TH isoform 3; TH isoform a; TH-4; TPL 2; Tpl2; TPL-2; Tumor progression locus 2; TY3H; TYH
Gene Symbols MAP3K8
Host Species Rabbit
Immunogen KLH conjugated synthetic phosphopeptide derived from human MAP3K8/Tpl2 around the phosphorylation site of Thr290.
Purification Method Protein A
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 1326
Target Species Human
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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