Phospho-MEF2C (Ser387) Rabbit anti-Human, Polyclonal, Bioss

Rabbit Polyclonal Antibody

Supplier:  Bioss BS5481R

Catalog No. 50-198-6598

Description

MEF2C is a transcription activator which binds specifically to the MEF2 element present in the regulatory regions of many muscle-specific genes. Controls cardiac morphogenesis and myogenesis, and is also involved in vascular development. Plays an essential role in hippocampal-dependent learning and memory by suppressing the number of excitatory synapses and thus regulating basal and evoked synaptic transmission. Crucial for normal neuronal development, distribution, and electrical activity in the neocortex. Necessary for proper development of megakaryocytes and platelets and for bone marrow B lymphopoiesis. Required for B-cell survival and proliferation in response to BCR stimulation, efficient IgG1 antibody responses to T-cell-dependent antigens and for normal induction of germinal center B cells. May also be involved in neurogenesis and in the development of cortical architecture. Isoform 3 and isoform 4, which lack the repressor domain, are more active than isoform 1 and isoform 2.

Specifications

• Antigen: Phospho-MEF2C (Ser387)
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: MEF2C
• Gene Alias: 5430401D19Rik; 9930028G15Rik; AV011172; C5DELq14.3; DEL5q14.3; MADS box transcription enhancer factor 2, polypeptide C; Mef2; Mef2c; Myocyte enhancer factor 2C; Myocyte-specific enhancer factor 2C; RGD1563119
• Host Species: Rabbit
• Purification Method: Protein A
• Regulatory Status: RUO
• Gene ID (Entrez): 4208
• Content And Storage: -20°C
• Form: Liquid

• Applications: Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
• Concentration: 1 μg/mL
• Formulation: PBS with 1% BSA, 50% glycerol and 0.09% sodium azide; pH
• Gene Accession No.: Q06413
• Gene Symbols: MEF2C
• Immunogen: KLH conjugated synthetic phosphopeptide derived from human MEF2C around the phosphorylation site of Ser387.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG