Invitrogen™ Phospho-MEK1/MEK2 (Ser221) Recombinant Rabbit Monoclonal Antibody (MEK12S221-D3)

Rabbit Recombinant Monoclonal Antibody

Catalog Number	Mfr. No.	Quantity
PIMA528038	Invitrogen™ MA528038	200 μL
PIMA537076	Invitrogen™ MA537076	20 μL

Description

Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.

MEK 1 (MAP Kinase Kinase, also known as MKK) is an integral component of the MAP kinase cascade that regulates cell growth and differentiation (Ahn, 1993; Chong et al., 2003). In brain, this pathway also plays a key role in synaptic (Adams and Sweatt, 2002). Activated MEK 1 acts as a dual specificity kinase phosphorylating both a threonine and a tyrosine residue on MAP kinase (Kyriakis et al., 1991; Seger et al., 1991; Crews et al., 1992).

Specifications

• Antigen: Phospho-MEK1/MEK2 (Ser221)
• Concentration: 0.5 mg/mL
• Applications: Flow Cytometry, Western Blot
• Conjugate: Unconjugated
• Host Species: Rabbit
• Regulatory Status: RUO
• Formulation: PBS with 0.1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.4
• Gene Accession No.: P31938, P36507, Q02750, Q63932
• Gene ID (Entrez): 26395, 26396, 5604, 5605
• Immunogen: A synthetic phospho-peptide corresponding to residues surrounding Ser221 of human phospho MEK1/2.
• Product Type: Antibody

• Clone: MEK12S221-D3
• Content And Storage: -20°C
• Classification: Recombinant Monoclonal
• Form: Liquid
• Isotype: IgG κ
• Target Species: Human, Mouse
• Gene: MAP2K2
• Gene Alias: AA589381; CFC3; CFC4; dual specificity mitogen activated protein kinase kinase 1; dual specificity mitogen-activated protein kinase kinase 1; Dual specificity mitogen-activated protein kinase kinase 2; EC 2.7.12.2; ERK activator kinase 1; ERK activator kinase 2; hypothetical protein; hypothetical protein LOC406728; kinase MEK1; MAP kinase kinase 1; MAP kinase kinase 2; MAP kinase/Erk kinase; MAP kinase/Erk kinase 1; Map2k1; Map2k2; MAPK/ERK kinase 1; MAPK/ERK kinase 2; MAPKK 1; MAPKK 2; MAPKK1; MAPKK2; MEK 1; MEK 2; Mek1; MEK-1; Mek2; MEK-2; MEKK1; mitogen activated protein kinase kinase 1; mitogen activated protein kinase kinase 2; mitogen-activated protein kinase kinase 1; mitogen-activated protein kinase kinase 2; mitogen-activated protein kinase kinase 2, p45; mitogen-activated protein kinase kinase type 2; MK2; MKK1; MKK2; MP2K1; PRKMK1; PRKMK2; protein kinase, mitogen activated, kinase 1, p45; protein kinase, mitogen activated, kinase 2, p45; protein kinase, mitogen-activated, kinase 1 (MAP kinase kinase 1); si:ch211-242m18.2; wu:fj56a12; wu:fj61b01; zgc:56557; zgc:56557 protein
• Gene Symbols: MAP2K1, MAP2K2
• Primary or Secondary: Primary
• Purification Method: Protein A/G