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Invitrogen™ Phospho-MER/SKY (Tyr749, Tyr681) Polyclonal Antibody
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Catalog No. PA540270
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100 μL
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PA540270 100 μL
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Catalog No. PA540270 Supplier Invitrogen™ Supplier No. PA540270
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Description

Rabbit Polyclonal Antibody

This antibody is predicted to react with mouse and rat based on sequence homology.

Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to several ligands including LGALS3, TUB, TULP1 or GAS6. Regulates many physiological processes including cell survival, migration, differentiation, and phagocytosis of apoptotic cells (efferocytosis). Ligand binding at the cell surface induces autophosphorylation of MERTK on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with GRB2 or PLCG2 and induces phosphorylation of MAPK1, MAPK2, FAK/PTK2 or RAC1. MERTK signaling plays a role in various processes such as macrophage clearance of apoptotic cells, platelet aggregation, cytoskeleton reorganization and engulfment. Functions in the retinal pigment epithelium (RPE) as a regulator of rod outer segments fragments phagocytosis. Plays also an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response by activating STAT1, which selectively induces production of suppressors of cytokine signaling SOCS1 and SOCS3.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Phospho-MER/SKY (Tyr749, Tyr681)
Applications ELISA, Immunohistochemistry, Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol, 0.5% BSA and 0.02% sodium azide; pH 7.4
Gene MERTK
Gene Accession No. P55144, P55146, P57097, Q06418, Q12866, Q60805
Gene Alias AI323366; Brt; Bruton agammaglobulinemia tyrosine kinase; BYK; c-Eyk; c-mer; c-mer proto-oncogene tyrosine kinase; Dtk; EC 2.7.10.2; Etk-2; etk2/tyro3; Eyk; kinase Syk; KSYK; Mer; MER proto-oncogene, tyrosine kinase; MER receptor tyrosine kinase; MERTK; nmf12; Nyk; Proto-oncogene c-Mer; proto-oncogene tyrosine-protein kinase MER; rdy; Receptor tyrosine kinase MerTK; Receptor tyrosine tinase gene probably the gene for Rdy; Rek; retinal dystrophy; RP38; RSE; Sky; sMER; sMERTK; soluble MER; soluble MERTK; STK kinase; SYK; Tif; TK19-2; Tyro 12; Tyro12; Tyro3; TYRO3 protein tyrosine kinase; TYRO3 protein tyrosine kinase 3; tyrosine-protein kinase byk; Tyrosine-protein kinase DTK; tyrosine-protein kinase Mer; Tyrosine-protein kinase receptor TYRO3; tyrosine-protein kinase RSE; Tyrosine-protein kinase SKY; tyrosine-protein kinase TIF
Gene Symbols MERTK, TYRO3
Host Species Rabbit
Immunogen Synthesized peptide derived from human MerTK/Tyro3 around the phosphorylation site of Y749/681.
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 10461, 17289, 22174, 25232, 65037, 7301
Target Species Human, Mouse, Rat
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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