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Phospho-MSK1 (Thr581) Rabbit anti-Human, Mouse, Rat, Invitrogen™

Rabbit Recombinant Monoclonal Antibody

Manufacturer:  Invitrogen MA528080

Catalog No. PIMA528080


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Description

Description

Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using Recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.

MSK-1 is a mitogen and stress activated protein kinase-1 which belongs to the AGC family of kinases and is related in structure to the ribosomal p70 S6 kinase subfamily. MSK-1 can be activated by ERK1/2 and SAPK2 /p38 MAP kinase. It is also known to be required for the phosphorylation of CREB, ATF1 H3 and HMG-14 in response to mitogen and stress. Similar to RSK, MSK-1 contains two kinase domains (N-term and a C-term). Once phosphorylated on Thr581 and Ser360 by ERK1/2 and SAPK2/p38, MSK-1 autophosphorylate on at least 5 sites. Of these autophosphorylation sites Ser212 and Ser376 get phosphorylated by the C-terminal kinase domain of MSK-1 which is essential for the catalytic activity of the N-terminal kinase domain.
Specifications

Specifications

Phospho-MSK1 (Thr581)
Recombinant Monoclonal
0.5 mg/ml
PBS with 0.1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.4
O75582, Q8C050
RPS6KA5
A synthetic phospho-peptide corresponding to residues surrounding Thr581 of human phospho MSK1
Protein A/G
RUO
Antibody
Monoclonal
Human, Mouse, Rat
Flow Cytometry, Western Blot
MSK1T581-A5
Unconjugated
RPS6KA5
Liquid
Rabbit
IgG1, kappa
200 μl
-20°C
Primary
314384, 73086, 9252
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