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Phospho-MST1 (Thr183) Rabbit anti-Human, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA540177

Catalog No. PA540177


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Description

Description

This antibody is predicted to react with mouse based on sequence homology. The antibody detects endogenous levels of Mst1 only when phosphorylated at threonine 183.

Stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation. Key component of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. STK3/MST2 and STK4/MST1 are required to repress proliferation of mature hepatocytes, to prevent activation of facultative adult liver stem cells (oval cells), and to inhibit tumor formation By similarity.
Specifications

Specifications

Phospho-MST1 (Thr183)
Polyclonal
Unconjugated
STK3
Liquid
STK3, STK4
Peptide sequence around phosphorylation site of threonine 183 (R-N-T(p)-V-I) derived from Human Mst1.
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human
Immunohistochemistry (Paraffin), Western Blot
1 mg/mL
PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Q13043, Q13188
EC 2.7.11.1, MST-1, Mammalian STE20-like protein kinase 1, STE20-like kinase MST1, STK4, Serine/threonine protein kinase 4, Serine/threonine protein kinase Krs-2, kinase MST1, serine/threonine kinase 4; STE20-like kinase MST1; Yeast Sps1/Ste20-related kin
Rabbit
IgG
100 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
6788, 6789
Documents
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