Phospho-MST1 (Thr183) Rabbit anti-Human, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA540177

Catalog No. PA540177

Description

This antibody is predicted to react with mouse based on sequence homology. The antibody detects endogenous levels of Mst1 only when phosphorylated at threonine 183.

Stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation. Key component of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. STK3/MST2 and STK4/MST1 are required to repress proliferation of mature hepatocytes, to prevent activation of facultative adult liver stem cells (oval cells), and to inhibit tumor formation By similarity.

Specifications

• Antigen: Phospho-MST1 (Thr183)
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: STK3
• Format: Liquid
• Gene Symbols: STK3, STK4
• Immunogen: Peptide sequence around phosphorylation site of threonine 183 (R-N-T(p)-V-I) derived from Human Mst1.
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Type: Antibody
• Monoclonal or Polyclonal: Polyclonal
• Target Species: Human

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Concentration: 1 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
• Gene Accession No.: Q13043, Q13188
• Gene Alias: EC 2.7.11.1, MST-1, Mammalian STE20-like protein kinase 1, STE20-like kinase MST1, STK4, Serine/threonine protein kinase 4, Serine/threonine protein kinase Krs-2, kinase MST1, serine/threonine kinase 4; STE20-like kinase MST1; Yeast Sps1/Ste20-related kin
• Host Species: Rabbit
• Isotype: IgG
• Quantity: 100 μL
• Storage Requirements: -20° C, Avoid Freeze/Thaw Cycles
• Primary or Secondary: Primary
• Gene ID (Entrez): 6788, 6789