Invitrogen™ Phospho-p38 MAPK Pan (Thr180, Tyr182, Thr183, Tyr185) Polyclonal Antibody

Catalog No.	Quantity
PIPA5121361	100 μL

Catalog No. PIPA5121361 Supplier Invitrogen™ Supplier No. PA5121361

Description

Rabbit Polyclonal Antibody

Positive test controls include: C6. Immunogen sequence: MTGYV.

The p38 MAPK cascade regulates a variety of cellular responses to stress, inflammation, and other signals. p38 MAPK is relatively inactive in the nonphosphorylated form and becomes rapidly activated by dual phosphorylation of a Thr-Gly-Tyr motifs. There are four isoforms of p38 MAPK, which differ in their tissue expression and affinity for upstream activators and downstream effectors. When cells are exposed to tumor necrosis factor, interleukin-1, heat shock, or other activating stimuli, activation of MAPK kinase-3 occurs by phosphorylation. Activated MAPK kinase-3/6 phosphorylate each residue of Thr180 and Tyr182 in p38 MAPK. Phospho-p38 MAPK activates ATF-2, CHOP-1, MEF-2 and other transcription factors through phosphorylation.

Specifications

• Antigen: Phospho-p38 MAPK Pan (Thr180, Tyr182, Thr183, Tyr185)
• Applications: ELISA, Western Blot
• Classification: Polyclonal
• Concentration: 0.26 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 50% glycerol and 0.05% ProClin 300; pH 7.3
• Gene: MAPK13
• Gene Accession No.: O15264, P53778, P70618, Q15759, Q16539, Q63538, Q9WTY9
• Gene Symbols: MAPK11, MAPK12, MAPK13, MAPK14
• Host Species: Rabbit
• Immunogen: Synthetic peptide.
• Purification Method: Affinity Chromatography
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 1432, 29513, 5600, 5603, 60352, 6300, 689314, 81649
• Target Species: Human, Rat
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG