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Invitrogen™ Phospho-PAK3 (Ser154) Polyclonal Antibody
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Catalog No. PIPA536866
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PIPA536866 100 μL
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Catalog No. PIPA536866 Supplier Invitrogen™ Supplier No. PA536866
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Description

Rabbit Polyclonal Antibody

This antibody detects endogenous protein at a molecular weight of 65 kDa. Purity is >95% by SDS-PAGE.

PAK proteins are critical effectors that link Rho GTPases to cytoskeleton reorganization and nuclear signaling. PAK proteins, a family of serine/threonine p21-activating kinases, serve as targets for the small GTP binding proteins Cdc42 and RAC and have been implicated in a wide range of biological activities. The alpha, beta and gammaPAK isoforms complex specifically with Rac1 and Cdc42 in their active GTP-bound state, inhibiting their intrinsic GTPase activity leading to their autophosphorylation. There are eight sites of autophosphorylation on gammaPAK, including Ser 19, Ser 141 and Thr 402, and phosphorylation of Ser 141 and Thr 402 is correlated with gammaPAK activation. Once phosphorylated and their affinity for Rac/Cdc42 reduced, the PAK isoforms disassociate from the complex to seek downstream substrates.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Phospho-PAK3 (Ser154)
Applications Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.2
Gene PAK3
Gene Accession No. O75914, Q61036, Q62829
Gene Alias 2.7.11.1; adriamycin resistance-associated; ARA; beta-PAK; bPAK; CDC42/RAC effector kinase PAK-B; CDKN1A; hPAK3; MRX30; MRX47; oligophrenin-3; OPHN3; p21 (CDKN1A)-activated kinase 3; p21 (RAC1) activated kinase 3; p21 protein (Cdc42/Rac)-activated kinase 3; p21/Cdc42/Rac1-activated kinase 3 (yeast Ste20-related); p21-activated kinase 3; p65-PAK; PAK beta; Pak3; Pak-3; PAK3beta; Pak65alpha; Pak65beta; Pakb; Serine/threonine-protein kinase PAK 3; Stk4
Gene Symbols PAK3
Host Species Rabbit
Immunogen Synthetic phosphopeptide derived from human PAK3 around the phosphorylation site of Serine 154.
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 18481, 29433, 5063
Target Species Human, Mouse, Rat
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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