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Invitrogen™ Phospho-PAR4 (Thr163) Polyclonal Antibody
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Catalog No. PIPA517343
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100 μL
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PIPA517343 100 μL
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Catalog No. PIPA517343 Supplier Invitrogen™ Supplier No. PA517343
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Description

Rabbit Polyclonal Antibody

It is not recommended to aliquot this antibody.

This gene encodes a tumor suppressor protein that selectively induces apoptosis in cancer cells through intracellular and extracellular mechanisms. The intracellular mechanism involves the inhibition of pro-survival pathways and the activation of Fas-mediated apoptosis, while the extracellular mechanism involves the binding of a secreted form of this protein to glucose regulated protein 78 (GRP78) on the cell surface, which leads to activation of the extrinsic apoptotic pathway. This gene is located on the unstable human chromosomal 12q21 region and is often deleted or mutated different tumors. The encoded protein also plays an important role in the progression of age-related diseases.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Phospho-PAR4 (Thr163)
Applications Western Blot
Classification Polyclonal
Concentration 190 μg/mL
Conjugate Unconjugated
Formulation 0.01M HEPES with 100μg/mL BSA, 50% glycerol, 0.15M NaCl and no preservative; pH 7.5
Gene Pawr
Gene Accession No. Q62627, Q925B0, Q96IZ0
Gene Alias 2310001G03Rik; coagulation factor II (thrombin) receptor-like 3; Coagulation factor II receptor-like 3; F2R like thrombin/trypsin receptor 3; F2RL3; PAR4; Par-4; par-4 induced by effectors of apoptosis; Pawr; PRKC apoptosis WT1 regulator protein; PRKC, apoptosis, WT1, regulator; pro-apoptotic WT1 regulator; prostate apoptosis response 4; prostate apoptosis response 4 protein; Prostate apoptosis response protein 4; prostate apoptosis response protein PAR-4; prostate apoptosis response-4; protease-activated receptor-4; proteinase-activated receptor 4; Thrombin receptor-like 3; transcriptional repressor PAR4; transcriptional repressor Par-4-like protein PAWR; WT1-interacting protein
Gene Symbols Pawr
Host Species Rabbit
Immunogen Synthetic peptide corresponding to residues surrounding Thr163 of human PAR-4 (Thr155 in rat and Thr156 in mouse).
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 114774, 5074, 64513
Target Species Human, Mouse, Monkey, Rat
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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