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Invitrogen™ Phospho-PDGFRB (Tyr740) Recombinant Rabbit Monoclonal Antibody (SN0646)
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Catalog No. PIMA542440
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100 μL
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PIMA542440 100 μL
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Catalog No. PIMA542440 Supplier Invitrogen™ Supplier No. MA542440
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Description

Rabbit Recombinant Monoclonal Antibody

Positive Control: C2C12, Hela, L6. Subcellular Location: Cell membrane, Cytoplasmic vesicle.

PDGFRB is a receptor tyrosine kinase and has been implicated in atherogenesis and in cell transformation by the SIS oncogene. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer or a heterodimer, composed of both platelet-derived growth factor receptor alpha and beta polypeptides. The gene is flanked on chromosome 5 by the genes for granulocyte-macrophage colony-stimulating factor and macrophage-colony stimulating factor receptor; all three genes may be implicated in the 5-q syndrome. A translocation between chromosomes 5 and 12, that fuses PDGFRB (CD140b) to that of the translocation, ETV6, leukemia gene, results in chronic myeloproliferative disorder with eosinophilia.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Phospho-PDGFRB (Tyr740)
Applications Western Blot, Immunocytochemistry
Classification Recombinant Monoclonal
Clone SN0646
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation TBS with 40% glycerol and 0.05% sodium azide; pH 7.4
Gene Pdgfrb
Gene Accession No. P09619, Q05030
Gene Alias AI528809; Beta platelet-derived growth factor receptor; beta-type platelet-derived growth factor receptor; CD140 antigen-like family member B; CD140B; CD140b antigen; IBGC4; IMF1; JTK12; KOGS; PDGF beta chain; PDGF Receptor beta; Pdgfr; Pdgfr1; PDGFR-1; PDGFRB; PDGF-R-beta; PDGFR-beta; PENTT; platelet derived growth factor receptor beta; platelet derived growth factor receptor, beta polypeptide; platelet-derived growth factor receptor 1; Platelet-derived growth factor receptor beta; platelet-derived growth factor receptor beta variant 1; Platelet-derived growth factor receptor, beta; platelet-derived growth factor receptor, beta polypeptide
Gene Symbols Pdgfrb
Host Species Rabbit
Immunogen Synthetic phospho-peptide corresponding to residues surrounding Tyr740 of human PDGFR beta.
Purification Method Protein A
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 24629, 5159
Target Species Human, Rat
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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