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Invitrogen™ Phospho-PFKFB3 (Ser461) Polyclonal Antibody
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Catalog No. PIPA5114619
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PIPA5114619 100 μL
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Catalog No. PIPA5114619 Supplier Invitrogen™ Supplier No. PA5114619
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Description

Rabbit Polyclonal Antibody

Antibody detects endogenous levels of PFKFB3 only when phosphorylated at Ser461.

The protein encoded by this gene belongs to a family of bifunctional proteins that are involved in both the synthesis and degradation of fructose-2,6-bisphosphate, a regulatory molecule that controls glycolysis in eukaryotes. The encoded protein has a 6-phosphofructo-2-kinase activity that catalyzes the synthesis of fructose-2,6-bisphosphate (F2,6BP), and a fructose-2,6-biphosphatase activity that catalyzes the degradation of F2,6BP. This protein is required for cell cycle progression and prevention of apoptosis. It functions as a regulator of cyclin-dependent kinase 1, linking glucose metabolism to cell proliferation and survival in tumor cells. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Phospho-PFKFB3 (Ser461)
Applications Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene PFKFB3
Gene Accession No. O35552, Q16875
Gene Alias 6-biphosphatase 3; 6PF-2-K/Fru-2,6-P2ase 3; 6PF-2-K/Fru-2,6-P2ase brain/placenta-type isozyme; 6PF-2-K/Fru-2,6-P2ASE brain-type isozyme; 6-phosphofructo-2-kinase; 6-phosphofructo-2-kinase/ fructose-2,6-bisphosphatase; 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3; 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3; E330010H22Rik; Fructose-2; Fructose-2,6-bisphosphatase; fructose-6-phosphate,2-kinase/fructose-2, 6-bisphosphatase; inducible 6-phosphofructo-2-kinase; inducible 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase; IPFK2; iPFK-2; PFK/FBPase 3; PFK2; PFKFB3; RB2K; renal carcinoma antigen NY-REN-56; RP11-298K24.3; uPFK-2
Gene Symbols PFKFB3
Host Species Rabbit
Immunogen A synthesized peptide derived from human PFKFB3 around the phosphorylation site of Ser461.
Purification Method Sequential chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 117276, 170768, 5209
Target Species Human, Mouse, Rat
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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