Invitrogen™ Phospho-Phospholamban (Ser16) Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA125784

Catalog No. PA125784

Description

Recommended positive controls: Bovine cardiac preparation. PA1-25784 is expected to cross react with rabbit, mouse, rat, canine, and porcine due to sequence homology. Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Phospholamban (PLB) is a 52 amino acid phosphoprotein which regulates the calcium pump of cardiac sarcoplasmic reticulum (SR). PLB is an oligomer of five identical subunits each having a cytoplasmic and transmembrane domain. The cytoplasmic domain (residues 1 to 25) contains the phosphorylation sites and is highly basic and readily cleaved by proteases whereas the transmembrane domain (residues 25 to 52) is mostly hydrophobic, protease resistant and stabilizes the pentamer.

Specifications

• Antigen: Phospho-Phospholamban (Ser16)
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: PLN
• Gene Alias: cardiac CMH18; Cardiac phospholamban; CMD1P; CMH18; phospholamban; Plb; Plm; PLN; unnamed protein product
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 100009299, 100125240, 5350
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Western Blot
• Concentration: 1 mg/mL
• Formulation: TBS with 30% glycerol and 0.05% sodium azide; pH 7.4
• Gene Accession No.: A4IFH6, P26678, P61015
• Gene Symbols: PLN
• Immunogen: Synthetic peptide, KLH-conjugated, corresponding to residues R(14) A [pS] T I E M P Q Q A R(25) C of human cardiac Phospholamban.
• Quantity: 50 μg
• Primary or Secondary: Primary
• Target Species: Human, Rabbit, Bovine
• Product Type: Antibody
• Isotype: IgG