Invitrogen™ Phospho-PINK1 (Ser228) Polyclonal Antibody

Catalog No.	Quantity
PIPA5105356	100 μL

Catalog No. PIPA5105356

Supplier: Invitrogen™ PA5105356

Description

Rabbit Polyclonal Antibody

Antibody detects endogenous levels of PINK1 only when phosphorylated at Ser228.

PINK1 (PTEN-induced putative kinase 1) protects from mitochondrial dysfunction in cells by conferring different autophosphorylation activity to mitochondrial genes. The kinase domain of PINK1 appears to be critical in its protective effects. Mitochondrial proteins are critical for the regulation of cellular energy and adaptation to stress. Particularly in brain cells, mitochondrial demand is extraordinarily high, in order to accommodate aerobic and anaerobic support of high energy processes. When mitochondrial structure and/or function is disrupted in the brain, neurodegenerative diseases like Parkinson's disease are triggered.

Specifications

• Antigen: Phospho-PINK1 (Ser228)
• Applications: Immunohistochemistry (Paraffin), Western Blot
• Classification: Polyclonal
• Concentration: 1 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
• Gene: PINK1
• Gene Accession No.: B5DFG1, Q99MQ3, Q9BXM7
• Gene Alias: 1190006F07Rik; AU042772; AW557854; BRPK; FLJ27236; mFLJ00387; PARK6; PINK 1; Pink1; PINK-1; protein kinase BRPK; PTEN induced putative kinase 1; PTEN-induced putative kinase protein 1; Serine/threonine-protein kinase PINK1, mitochondrial
• Gene Symbols: PINK1
• Host Species: Rabbit
• Immunogen: A synthesized peptide derived from human PINK1(Accession Q9BXM7), corresponding to amino acid residues around phosphorylated Ser228.
• Purification Method: Sequential Chromatography
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 298575, 65018, 68943
• Target Species: Human, Mouse, Rat
• Content And Storage: -20°C
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov