Phospho-PKA alpha/beta/gamma (Thr198) Polyclonal Antibody, Invitrogen™

Rabbit Polyclonal Antibody

Supplier:  Thermo Scientific PA5105515

Catalog No. PIPA5105515

Description

Antibody detects endogenous levels of PKA alpha/beta/gamma CAT only when phosphorylated at Thr198.

Protein kinase A (PKA, cAMP-dependent protein kinase) is a key element of a ubiquitous signaling pathway important in the cell cycle, cellular communication, memory formation and behavior. PKA is composed of two catalytic (PKAc; Protein Kinase A catalytic subunit) and two regulatory subunits (PKAr). Upon binding cAMP, the complex dissociates to PKAr dimer and two activated PKAc ser/thr protein kinase catalytic monomers. The released PKAc can translocate into the nucleus and exert a regulatory role in the activation of multiple nuclear hormone receptors. However, PKAc-mediated activation of tonicity-dependent gene expression is cAMP independent. Humans express three types of PKAc subunit - PKAc alpha is present in most human tissues, PKAc beta and gamma are tissue-specific, the later is found in testes.

Specifications

• Antigen: Phospho-PKA alpha/beta/gamma (Thr198)
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: PRKACB
• Gene Alias: BDPLT19, cAMP-dependent protein kinase catalytic beta subunit isoform 4ab, cAMP-dependent protein kinase catalytic subunit alpha, cAMP-dependent protein kinase catalytic subunit alpha, isoform 1, cAMP-dependent protein kinase catalytic subunit beta, cAMP-dependent protein kinase catalytic subunit gamma, KAPG, PKA C-alpha, PKA C-beta, PKA C-gamma, PKACA, PKACB, PKACg, PPNAD4, PRKACA, PRKACB, PRKACG, protein kinase A catalytic subunit, protein kinase A catalytic subunit beta, protein kinase cAMP-activated catalytic subunit alpha, protein kinase cAMP-activated catalytic subunit beta, protein kinase cAMP-activated catalytic subunit gamma, protein kinase, cAMP-dependent, alpha catalytic subunit, protein kinase, cAMP-dependent, beta catalytic subunit, protein kinase, cAMP-dependent, catalytic, alpha, protein kinase, cAMP-dependent, catalytic, beta, protein kinase, cAMP-dependent, catalytic, gamma, protein kinase, cAMP-dependent, gamma catalytic subunit, serine(threonine) protein kinase
• Host Species: Rabbit
• Purification Method: sequential chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 18747, 18749, 25636, 293508, 5566, 5567, 5568
• Content And Storage: -20°C
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Concentration: 1 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
• Gene Accession No.: P05132, P17612, P22612, P22694, P27791, P68181, P68182
• Gene Symbols: PRKACA, PRKACB, PRKACG
• Immunogen: A synthesized peptide derived from human PRKACA(Accession P17612), corresponding to amino acid residues around phosphorylated Thr198.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov