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Invitrogen™ Phospho-PYK2 (Tyr402) Polyclonal Antibody
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Catalog No. 44618G
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44-618-G 100 μL
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Catalog No. 44-618-G Supplier Invitrogen™ Supplier No. 44618G
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Description

Rabbit Polyclonal Antibody

This product contains enough material for 10 mini-blots. Antibody has been negatively preadsorbed using a nonphosphopeptide then purified by epitope-specific affinity chromatography. The antibody has been used in western blotting and immunohistochemistry. Other applications may work but have not been tested. Positive controls used were CEF cell extracts +/- Pyk2 transfection or A431 whole cell lysate.

PTK2B (FAK2) is a cytoplasmic tyrosine kinase involved in calcium-induced regulation of ion channels and activation of the map kinase signaling pathway. PTK2B regulates reorganization of the actin cytoskeleton, cell polarization, cell migration, adhesion, spreading, and bone remodeling. FAK2 plays a role in the regulation of the humoral immune response and is required for normal levels of marginal B-cells in the spleen and normal migration of splenic B-cells. It functions in signaling downstream of integrin and collagen receptors, immune receptors, G-protein coupled receptors, cytokine, chemokine, and growth factor receptors, and mediates responses to cellular stress. Aberrant FAK2 expression may play a role in cancer cell proliferation, migration, and invasion in tumor formation and metastasis. Elevated expression has been seen in gliomas, hepatocellular carcinoma, lung cancer, and breast cancer.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Phospho-PYK2 (Tyr402)
Applications Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration lot-specific
Conjugate Unconjugated
Formulation Dulbecco's PBS with 1mg/mL BSA and 0.05% sodium azide; pH 7.3
Gene PTK2B
Gene Accession No. P70600, Q14289, Q9QVP9
Gene Alias CADTK; CAK beta; CAKB; CAKbeta; CAK-beta; calcium-dependent tyrosine kinase; Calcium-regulated non-receptor proline-rich tyrosine kinase; cell adhesion kinase beta; cellular adhesion kinase beta; E430023O05Rik; FADK; FADK 2; FADK2; FAK; FAK1; FAK2; focal adhesion kinase 2; FRNK; PKB; pp125FAK; proline-rich tyrosine kinase 2; protein kinase B; protein tyrosine kinase 2 beta; protein-tyrosine kinase 2-beta; PTK; PTK2 protein tyrosine kinase 2 beta; PTK2B; PTK2B protein tyrosine kinase 2 beta; PYK2; RAFTK; related adhesion focal tyrosine kinase
Gene Symbols PTK2B
Host Species Rabbit
Immunogen The antiserum was produced against a chemically synthesized phosphopeptide derived from the region of human Pyk2 that contains tyrosine 402. The sequence is conserved in rat.
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 19229, 2185, 421998, 50646
Target Species Human, Mouse, Rat, Chicken
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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