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Phospho-Pyk2 (Tyr881) Rabbit anti-Human, Polyclonal, Bioss
SDP

Catalog No. 501985372
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50-198-5372 100 μL
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Catalog No. 50-198-5372 Supplier Bioss Supplier No. BS3401R
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Description

Rabbit Polyclonal Antibody

FAK2 (also known as PTK2B - Protein-tyrosine kinase 2-beta) is a non-receptor protein-tyrosine kinase that regulates reorganization of the actin cytoskeleton, cell polarization, cell migration, adhesion, spreading, and bone remodeling. FAK2 plays a role in the regulation of the humoral immune response and is required for normal levels of marginal B-cells in the spleen and normal migration of splenic B-cells. It functions in signaling downstream of integrin and collagen receptors, immune receptors, G-protein coupled receptors, cytokine, chemokine, and growth factor receptors, and mediates responses to cellular stress. Aberrant FAK2 expression may play a role in cancer cell proliferation, migration, and invasion in tumor formation and metastasis. Elevated expression has been seen in gliomas, hepatocellular carcinoma, lung cancer, and breast cancer.

Specifications

Antigen Phospho-Pyk2 (Tyr881)
Applications Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 1 μg/mL
Conjugate Unconjugated
Formulation PBS with 1% BSA, 50% glycerol and 0.09% sodium azide; pH
Gene PTK2B
Gene Accession No. Q14289
Gene Alias CADTK; CAK beta; CAKB; CAKbeta; CAK-beta; Calcium-dependent tyrosine kinase; Calcium-regulated non-receptor proline-rich tyrosine kinase; Cell adhesion kinase beta; cellular adhesion kinase beta; E430023O05Rik; FADK; FADK 2; FADK2; FAK; FAK1; FAK2; Focal adhesion kinase 2; FRNK; PKB; pp125FAK; Proline-rich tyrosine kinase 2; protein kinase B; protein tyrosine kinase 2 beta; Protein-tyrosine kinase 2-beta; PTK; PTK2 protein tyrosine kinase 2 beta; PTK2B; PTK2B protein tyrosine kinase 2 beta; PYK2; RAFTK; Related adhesion focal tyrosine kinase
Gene Symbols PTK2B
Host Species Rabbit
Immunogen KLH conjugated synthetic phosphopeptide derived from human Pyk2 around the phosphorylation site of Tyr881.
Purification Method Protein A
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 2185
Target Species Human
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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