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Invitrogen™ Phospho-RARA (Ser77) Polyclonal Antibody
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Catalog No. PIPA5118496
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PIPA5118496 100 μL
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Catalog No. PIPA5118496 Supplier Invitrogen™ Supplier No. PA5118496
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Description

Rabbit Polyclonal Antibody

Antibody detects endogenous levels of Retinoic Acid Receptor alpha only when phosphorylated at Sersine 77.

RARA is a receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RXR/RAR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. In the absence of ligand, the RXR-RAR heterodimers associate with a multiprotein complex containing transcription corepressors that induce histone acetylation, chromatin condensation and transcriptional suppression. On ligand binding, the corepressors dissociate from the receptors and associate with the coactivators leading to transcriptional activation. RARA plays an essential role in the regulation of retinoic acid-induced germ cell development during spermatogenesis. Has a role in the survival of early spermatocytes at the beginning prophase of meiosis. In Sertoli cells, may promote the survival and development of early meiotic prophase spermatocytes. In concert with RARG, required for skeletal growth, matrix homeostasis and growth plate function. Regulates expression of target genes in a ligand-dependent manner by recruiting chromatin complexes containing KMT2E/MLL5. Mediates retinoic acid-induced granulopoiesis.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Phospho-RARA (Ser77)
Applications Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene RARA
Gene Accession No. P10276, P11416
Gene Alias Nr1b1; nuclear receptor subfamily 1 group B member 1; nucleophosmin-retinoic acid receptor alpha fusion protein NPM-RAR long form; RAR; RAR Alpha; RAR alpha 1; RARA; RAR-alpha; RARalpha1; retinoic acid; retinoic acid nuclear receptor alpha variant 1; retinoic acid nuclear receptor alpha variant 2; retinoic acid receptor; retinoic acid receptor alpha; retinoic acid receptor, alpha; retinoic acid receptor, alpha polypeptide; RRA
Gene Symbols RARA
Host Species Rabbit
Immunogen A synthesized peptide derived from human RARA(Accession P10276), corresponding to amino acid residues around phosphorylated Ser77.
Purification Method Sequential Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 19401, 24705, 5914
Target Species Human, Mouse, Rat
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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