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Invitrogen™ Phospho-SF1 (Ser80, Ser82) Polyclonal Antibody
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Catalog No. PIPA5104263
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PIPA5104263 100 μL
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Catalog No. PIPA5104263 Supplier Invitrogen™ Supplier No. PA5104263
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Description

Rabbit Polyclonal Antibody

Antibody detects endogenous levels of SF1 only when phosphorylated at Ser80/82.

Splicing factor 1 is a nuclear pre-mRNA splicing factor. The protein specifically recognizes the intron branch point sequence at the 3' splice site, together with the large subunit of U2 auxiliary factor (U2AF), and is required for the early stages of spliceosome assembly. It also plays a role in nuclear pre-mRNA retention and transcriptional repression. The protein contains an N-terminal U2AF ligand motif, a central hnRNP K homology motif and quaking 2 region which bind a key branch-site adenosine within the branch point sequence, a zinc knuckles domain, and a C-terminal proline-rich domain. Alternative splicing results in multiple transcript variants.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Phospho-SF1 (Ser80, Ser82)
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene SF1
Gene Accession No. Q15637, Q64213
Gene Alias BBP; D11S636; M ZFM1; Mammalian branch point-binding protein; MBBP; MZFM; SF; SF1; Splicing factor 1; transcription factor ZFM1; WBP4; wu:fc09f06; ZCCHC25; ZFM1; Zfp162; Zinc finger gene in MEN1 locus; zinc finger protein 162; ZNF162
Gene Symbols SF1
Host Species Rabbit
Immunogen A synthesized peptide derived from human SF1(Accession Q15637), corresponding to amino acid residues around phosphorylated Ser82.
Purification Method sequential chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 117855, 22668, 7536
Target Species Human, Mouse, Rat, Monkey
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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