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Invitrogen™ Phospho-SKI (Ser383) Polyclonal Antibody
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Catalog No. PIPA5105311
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100 μL
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PIPA5105311 100 μL
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Catalog No. PIPA5105311 Supplier Invitrogen™ Supplier No. PA5105311
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Description

Rabbit Polyclonal Antibody

Antibody detects endogenous levels of SKI only when phosphorylated at Ser383.

TGF-beta is a ubiquitously expressed cytokine that signals through the Smad protein family to regulate numerous cellular processes such as embryonic development and tumorigenesis. This signaling is negatively regulated by Ski, the mammalian homolog of the transforming protein of an avian retrovirus that induces oncogenic transformation of chicken embryo cells, and the related protein SnoN. Ski functions by binding to the Smad proteins and preventing their phosphorylation, thereby inhibiting their ability to bind DNA and activate the transcription of downstream genes. Ski will also bind to the Smad proteins specific to bone morphogenic proteins (BMPs) and block BMP signaling in mammalian cells.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Phospho-SKI (Ser383)
Applications Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene SKI
Gene Accession No. P12755, Q60698
Gene Alias 2310012I02Rik; 2610001A11Rik; AA062172; AA589460; BC004088; C-ski; Proto-oncogene c-Ski; RGD1565591; SGS; SKI; Ski oncogene; ski oncoprotein; SKI proto-oncogene; ski sarcoma viral oncogene homolog; ski sarcoma viral oncogene homolog (avian); SKV; Sloan-Kettering viral oncogene homolog; v-ski avian sarcoma viral oncogene homolog
Gene Symbols SKI
Host Species Rabbit
Immunogen A synthesized peptide derived from human SKI(Accession P12755), corresponding to amino acid residues around phosphorylated Ser383.
Purification Method Sequential chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 20481, 313757, 6497
Target Species Human, Mouse, Rat
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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