Invitrogen™ Phospho-Stat1 (Tyr701) Recombinant Rabbit Monoclonal Antibody (Stat1Y701-3E6), APC, Invitrogen™

Rabbit Recombinant Monoclonal Antibody

Supplier:  Invitrogen™ MA537041

Catalog No. PIMA537041

Description

STAT1 (signal transducers and activators of transcription 1) is a member of the STAT family of transcription factors. STAT1 can be activated by interferon-alpha, interferon-gamma, EGF, PDGF and IL6. STAT1 is known to regulate several genes which are involved in cell growth, apoptosis, immune responses, and lipid metabolism. Further, STAT1 plays an important role in mediating cell viability in response to different cell stimuli and pathogen exposure. The STAT1 gene is located on chromosome 2. STAT1 is activated to regulate gene expression in response to extracellular signaling polypeptides including cytokines, interferons, and growth factors. After phosphorylation by JAK tyrosine kinases, STAT1 enters the nucleus to regulate transcription of many different genes. Among the seven STATs types, STAT1, STAT3, STAT5a, and STAT5b have a wide activation profile. STAT1 is activated by many different ligands including IFN family (IFN-Alpha, IFN-Beta, IFN-gamma and IL-10), gp130 family (IL-6, IL-11, LIF, CNTF, and G-CSF), and receptor tyrosine kinases (EGF, PDGF, and CSF-1). Two alternatively spliced transcript variants encoding distinct isoforms of STAT1 have been described.

Specifications

• Antigen: Phospho-Stat1 (Tyr701)
• Classification: Recombinant Monoclonal
• Conjugate: APC
• Gene: STAT1
• Gene Alias: 2010005J02Rik; AA408197; CANDF7; DD6G4-4; DKFZp686B04100; IMD31A; IMD31B; IMD31C; ISGF-3; LOW QUALITY PROTEIN: signal transducer and activator of transcription 1-alpha/beta; OTTHUMP00000165046; OTTHUMP00000205845; signal transducer and activator of transcription 1; signal transducer and activator of transcription 1, 91kD; signal transducer and activator of transcription 1, 91kDa; signal transducer and activator of transcription 1-alpha/beta; signal transducer and activator of transcription-1; STAT; STAT 1; STAT1; STAT-1; stat1 alpha; STAT91; transcription factor ISGF-3; transcription factor ISGF-3 components p91/p84
• Host Species: Rabbit
• Purification Method: Protein A/G
• Regulatory Status: RUO
• Gene ID (Entrez): 20846, 6772
• Content And Storage: 4°C
• Form: Liquid

• Applications: Flow Cytometry
• Clone: Stat1Y701-3E6
• Formulation: PBS with 0.20% BSA and 0.09% sodium azide
• Gene Accession No.: P42224, P42225
• Gene Symbols: STAT1
• Immunogen: A synthetic phospho-peptide corresponding to residues surrounding Tyr701 of human phospho Stat1.
• Quantity: 100 Tests
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG κ

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov