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Invitrogen™ Phospho-STAT5 alpha/beta (Ser726, Ser731) Polyclonal Antibody
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Catalog No. PIPA5104895
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PIPA5104895 100 μL
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Catalog No. PIPA5104895 Supplier Invitrogen™ Supplier No. PA5104895
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Description

Rabbit Polyclonal Antibody

Antibody detects endogenous levels of STAT5 only when phosphorylated at Ser726/Ser731, which site historically referenced as Ser725/Ser730.

The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor-associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated by, and mediates the responses of, many cell ligands, such as IL-2, IL-3, IL-7, GM-CSF, erythropoietin, thrombopoietin, and different growth hormones. Activation of this protein in myeloma and lymphoma associated with a TEL/JAK2 gene fusion is independent of cell stimulus and has been shown to be essential for the tumorigenesis. The mouse counterpart of this gene is found to induce the expression of BCL2L1/ BCL-X(L), which suggests the antiapoptotic function of this gene in cells.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Phospho-STAT5 alpha/beta (Ser726, Ser731)
Applications Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene STAT5A
Gene Accession No. P42229, P42230, P42232, P51692, P52632, Q62771
Gene Alias AA959963; Mammary gland factor; mammary gland factor STAT5A; mammary gland factor STAT5B; mammary gland factor; transcription factor; MGF; Mpf; signal transducer and activator of transcription 5; Signal transducer and activator of transcription 5a; Signal transducer and activator of transcription 5B; STA5B; STAT; STAT5; Stat5a; Stat5b; transcription factor STAT5B
Gene Symbols STAT5A, STAT5B
Host Species Rabbit
Immunogen A synthesized peptide derived from human STAT5A(Accession P42229), corresponding to amino acid residues around phosphorylated Ser726.
Purification Method sequential chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 20850, 20851, 24918, 25126, 6776, 6777
Target Species Human, Mouse, Rat
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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