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ABclonal Technology Phospho-STING/TMEM173-S366
Supplier: ABclonal Technology AP1369100UL
This gene encodes a five transmembrane protein that functions as a major regulator of the innate immune response to viral and bacterial infections The encoded protein is a pattern recognition receptor that detects cytosolic nucleic acids and transmits signals that activate type I interferon responses The encoded protein has also been shown to play a role in apoptotic signaling by associating with type II major histocompatibility complex Mutations in this gene are the cause of infantile-onset STING-associated vasculopathy Alternate splicing results in multiple transcript variants
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