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Invitrogen™ Phospho-TDP-43 (Ser409, Ser410) Polyclonal Antibody
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Catalog No. PIPA5121353
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PIPA5121353 100 μL
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Catalog No. PIPA5121353 Supplier Invitrogen™ Supplier No. PA5121353
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Description

Rabbit Polyclonal Antibody

The target is usually found in the following locations: Nucleus. Immunogen sequence: SKSSGW.

TDP43 was first identified as a novel cellular protein that binds to HIV-1 virus TAR DNA sequence motifs and acts a transcriptional repressor to the HIV-1 LTR. Later experiments revealed that TDP43 also regulates the splicing of exon 9 of the cystic fibrosis transmembrane conductance regular (CFTR), most likely through the association with the UG repeats at the 3e; splice site. A hyperphosphorylated, ubiquitinated, and cleaved form of TDP43 known as pathologic TDP43 is the major disease protein in ubiquitin-positive, tau-, and alpha-synuclein-negative frontotemporal dementia (FLTD-U). TDP43 is not related to TRBP1, and RNA binding protein that binds HIV-1 TAR RNA sequences.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Phospho-TDP-43 (Ser409, Ser410)
Applications Dot Blot, ELISA, Western Blot
Classification Polyclonal
Concentration 1.01 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.05% ProClin 300; pH 7.3
Gene TARDBP
Gene Accession No. Q13148
Gene Alias 1190002A23Rik; ALS10; C85084; hypothetical protein; OTTHUMP00000002171; OTTHUMP00000002173; RCJMB04_5g9; RP4-635E18.2; TAR DNA binding protein; TAR DNA binding protein L homeolog; TAR DNA-binding protein 43; TAR DNA-binding protein-43; tardbp; tardbp.L; Tdp43; TDP-43; wu:fb77f02; wu:fc52g10; XELAEV_18035188mg
Gene Symbols TARDBP
Host Species Rabbit
Immunogen A synthetic phosphorylated peptide around S409 & S410 of human TDP-43/TARDB (NP_031401.1).
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 23435
Target Species Human
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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