Invitrogen™ Phospho-TK1 (Ser13) Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5104737

Catalog No. PIPA5104737

Description

Antibody detects endogenous levels of Thymidine Kinase 1/TK1 only when phosphorylated at Serine 13.

Thymidine Kinase (TK1) is a highly conserved phosphotransferase that is present in most living cells. Thymidine Kinase catalyzes the phosphorylation reaction: deoxythymidine + ATP = deoxythymidine 5'-phosphate + ADP; it is thus involved in the reaction chain to introduce deoxythymidine into the DNA. Thymidine kinase is required for the action of many antiviral drugs, such as azidothymidine (AZT), and is also used to select hybridoma cell lines in the production of monoclonal antibodies. Thymidine Kinase has many clinical applications as it is only present in anticipation of cell division.

Specifications

• Antigen: Phospho-TK1 (Ser13)
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: TK1
• Gene Alias: D530002A18Rik; EC 2.7.1.21; KITH; thymidine kinase 1; thymidine kinase 1 soluble isoform; thymidine kinase 1, soluble; thymidine kinase, cytosolic; thymidine kinase-1; Tk; Tk1; Tk-1; Tk1a; Tk1b; TK2
• Host Species: Rabbit
• Purification Method: Sequential Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 21877, 24834, 7083
• Content And Storage: -20°C
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Concentration: 1 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
• Gene Accession No.: P04183, P04184, P27158
• Gene Symbols: TK1
• Immunogen: A synthesized peptide derived from human TK1(Accession P04183), corresponding to amino acid residues around phosphorylated Ser13.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

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