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Invitrogen™ Phospho-TLK1 (Ser743) Polyclonal Antibody
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Catalog No. PIPA5104670
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PIPA5104670 100 μL
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Catalog No. PIPA5104670 Supplier Invitrogen™ Supplier No. PA5104670
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Description

Rabbit Polyclonal Antibody

Antibody detects endogenous levels of TLK1 only when phosphorylated at Ser743.

TLK1 or tousled-like kinase 1 is a nuclear serine/threonine kinase that is potentially involved in the regulation of chromatin assembly. TLK1 is first described in Arabidopsis. TLK1 is a novel target of the DNA damage checkpoint that is rapidly inactivated upon exposure to ionizing radiation (IR) and the inactivation is directly mediated by the S-phase DNA damage checkpoint. The suppression of TLK1 activity after double-strand breaks in the DNA, replication blockade, or low doses of ultraviolet irradiation requires ATM, NBS and CHK1. The Tousled-like kinases, first described in Arabadopsis, are nuclear serine/threonine kinases that are potentially involved in the regulation of chromatin assembly.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Phospho-TLK1 (Ser743)
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene TLK1
Gene Accession No. Q8C0V0, Q9UKI8
Gene Alias 4930545J15Rik; E(Sp1) homolog; Enhancer of split groucho-like protein 1; ESG; ESG1; GRG1; KIAA0137; PKU beta; PKU-beta; serine threonine protein kinase; serine/threonine-protein kinase tousled-like 1; SNAK; SNARE protein kinase SNAK; TLE1; TLK1; TLK-1; TLK1B; tousled like kinase 1; tousled-like kinase 1; transducin like enhancer of split 1; transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila); transducin-like enhancer protein 1
Gene Symbols TLK1
Host Species Rabbit
Immunogen A synthesized peptide derived from human TLK1(Accession Q9UKI8), corresponding to amino acid residues around phosphorylated Ser743.
Purification Method sequential chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 228012, 9874
Target Species Human, Mouse
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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