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Phospho-TPH (Ser260) Rabbit anti-Human, Polyclonal, Bioss
SDP

Catalog No. 501986675
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50-198-6675 100 μL
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Catalog No. 50-198-6675 Supplier Bioss Supplier No. BS5601R
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Description

Rabbit Polyclonal Antibody

Tryptophan hydroxylase (TPH) catalyzes the 5-hydroxylation of tryptophan, which is the first step in the biosynthesis of indoleamines (serotonin and melatonin) (Martinez et al., 2001). In mammals, serotonin biosynthesis occurs predominantly in neurons which originate in the Raphe nuclei of the brain, and melatonin synthesis takes place within the pineal gland. Although TPH catalyzes the same reaction within the Raphe nuclei and the pineal gland, TPH activity is rate-limiting for serotonin but not melatonin biosynthesis. Serotonin functions mainly as a neurotransmitter, whereas melatonin is the principal hormone secreted by the pineal gland. The activity of TPH is enhanced by phosphorylation by cAMP-dependent protein kinase (PKA) and Ca2+/calmodulin kinase II (CAM K II) (Jiang et al., 2000; Johansen et al., 1996). Both PKA and CAM K II phosphorylate Ser58 which lies within the regulatory domain of TPH (Kuhn et al., 1997).

Specifications

Antigen Phospho-TPH (Ser260)
Applications Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 1 μg/mL
Conjugate Unconjugated
Formulation PBS with 1% BSA, 50% glycerol and 0.09% sodium azide; pH
Gene Tph2
Gene Accession No. P17752, Q8IWU9
Gene Alias ADHD7; indoleacetic acid-5-hydroxylase; LOC100344397; L-tryptophan hydroxylase; MGC119994; Neuronal tryptophan hydroxylase; NTPH; TPH; TPH1; Tph2; TPRH; TRPH; Tryptophan 5-hydroxylase 1; Tryptophan 5-hydroxylase 2; Tryptophan 5-monooxygenase 1; Tryptophan 5-monooxygenase 2; tryptophan hydroxylase (tryptophan 5-monooxygenase); tryptophan hydroxylase 1; tryptophan hydroxylase 1 (tryptophan 5-monooxygenase); tryptophan hydroxylase 2
Gene Symbols TPH1, Tph2
Host Species Rabbit
Immunogen KLH conjugated synthetic phosphopeptide derived from human TPH around the phosphorylation site of Ser260.
Purification Method Protein A
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 121278, 7166
Target Species Human
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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