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Invitrogen™ Phospho-Trf2 (Thr188) Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5105937

Catalog No. PIPA5105937


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Description

Description

Antibody detects endogenous levels of TRF2 only when phosphorylated at Thr188.

TRF2 is a ubiquitously expressed protein that is implicated in the control of telomere length. TRF2, like TRF1 contains a Myb-related DNA binding motif. It binds to duplex TTAGGG repeats and is localized to all human telomeres in metaphase chromosomes. TRF2 is thought to protect chromosome ends by maintaining the correct structure at telomere termini. The use of mutant forms of TRF2 has implicated a role for TRF2 in the prevention of senescence in primary human cells. Recently, it has been shown that inhibition of TRF2 resulted in apoptosis in a subset of mammalian cell types.
TRUSTED_SUSTAINABILITY
Specifications

Specifications

Phospho-Trf2 (Thr188)
Polyclonal
Unconjugated
TERF2
Telomeric DNA-binding protein; telomeric repeat binding factor 2; telomeric repeat binding protein 2; telomeric repeat-binding factor 2; TERF2; TRBF2; TRF2; TTAGGG repeat-binding factor 2
Rabbit
Sequential Chromatography
RUO
21750, 361403, 7014
-20°C
Liquid
Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
1 mg/mL
PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
O35144, Q15554
TERF2
A synthesized peptide derived from human TERF2(Accession Q15554), corresponding to amino acid residues around phosphorylated Thr188.
100 μL
Primary
Human, Mouse, Rat
Antibody
IgG
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