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Invitrogen™ Phospho-VASP (Thr278) Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5143786

Catalog No. PIPA5143786


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Description

Description

The antibody detects a 50 kDa* band corresponding to VASP in Western blots of human A431 and HeLa cells, as well as mouse C2C12 cells that have been treated with calyculin A.

Vasodilator-stimulated phosphoprotein (VASP) is a member of the Ena-VASP protein family. Ena-VASP family members contain an EHV1 N-terminal domain that binds proteins containing E/DFPPPPXD/E motifs and targets Ena-VASP proteins to focal adhesions. In the mid-region of the protein, family members have a proline-rich domain that binds SH3 and WW domain-containing proteins. Their C-terminal EVH2 domain mediates tetramerization and binds both G and F actin. VASP is associated with filamentous actin formation and likely plays a widespread role in cell adhesion and motility. VASP may also be involved in the intracellular signaling pathways that regulate integrin-extracellular matrix interactions. VASP is regulated by the cyclic nucleotide-dependent kinases PKA and PKG.
TRUSTED_SUSTAINABILITY
Specifications

Specifications

Phospho-VASP (Thr278)
Polyclonal
Unconjugated
VASP
Enah/Vasp-like; I79_012660; Unknown (protein for MGC:127789); vasodilator stimulated phosphoprotein; vasodilator-stimulated phosphoprotein; vasodilator-stimulated phosphoprotein (VASP); VASP
Rabbit
Antigen affinity chromatography
RUO
22323, 361517, 7408
-20°C, Avoid Freeze/Thaw Cycles
Liquid
Western Blot, Immunocytochemistry
0.25 mg/mL
PBS with 1mg/mL BSA, 50% glycerol and 0.05% sodium azide
P50552, P70460
VASP
Phospho-VASP (Thr-278) synthetic peptide (coupled to carrier protein) corresponding to amino acids surrounding threonine 278 in human VASP. This sequence has significant homology to the conserved site in rat and mouse VASP, but is not conserved in mena or EVL proteins.
100 μL
Primary
Human, Mouse, Rat
Antibody
IgG
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